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Exam 3-2005Key - NAME_KEY BIO 361 EXAM 3 ID FALL 2005...

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NAME:_____KEY ____________________ ID:_________________________ 1 BIO 361 EXAM 3 FALL 2005 NAME:_____________KEY ______________________________ ID:_____________________________________________________ 1. Write Your name and ID on all pages 2. Write all answers in pen only 3. Limit your answers to the space provided 4. Make sure your exam has seven pages including this cover page Page 2 _______________ Page 3 _______________ Page 4 _______________ Page 5 _______________ Page 6 _______________ Page 7 _______________ Total _______________ Maximum of 100 points
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NAME:_________KEY _____________ ID:_________________________ 2 1. For the committed step in the glycolytic pathway: a. Provide a balanced equation (include names and structures of the intermediates, but just names for any cofactors) (6 points) b. Name the enzyme that catalyzes the reaction. (2 points) c. This reaction is strongly inhibited by ATP. Nonetheless, glycolysis proceeds in liver even in the presence of high ATP concentration. How is this so? (4 points) d. Under what physiological conditions does glycolysis proceed in the liver even when ATP levels are high (provide both the physiological state and the predominant hormone)? (2 points) e. Why does glycolysis need to proceed in liver under the conditions described in “d” above? (2 points) a. b. Phosphofructokinase-1 c. Liver has Fructose 2,6 bisphosphate (Fru2,6BP) which relieves the ATP inhibition. d. The fed state (or high blood glucose). The predominant hormone is insulin. e. Liver stores the carbons in glucose as fatty acids. Glycolysis needs to proceed to form pyruvate and acetyl-CoA, which are the building blocks for fatty acids. CH 2 - OH C = O HO - C – H H - C – OH H - C – OH CH 2 – O - P + ATP CH 2 – O - P C = O HO - C – H H - C – OH H - C – OH CH 2 – O - P + ADP Fructose 6-phosphate (Fru6P) Fructose 1, 6-bisphosphate (Fru1,6BP)
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NAME:_________KEY _____________ ID:_________________________ 3 2. For the phosphoglycerate kinase reaction: a. Provide a balanced equation (include names and structures of substrates and products, just names for cofactors). (6 points) b. One of the substrates has a bond with sufficient energy to drive the synthesis of ATP. Circle and name this bond. (2 points) c. Explain where the energy in the bond circled in “b” came from. Include in your answer mechanistic details of how the energy was generated and how it was conserved in the bond. (4 points) a.
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