Exam2-2006Key - BIO 361 EXAM 2 FALL 2006 NAME:_KEY_ ID:_ 1....

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BIO 361 EXAM 2 FALL 2006 NAME:__________KEY_______________________________________ ID:_____________________________________________________ 1. Write Your name and ID on all pages 2. Write all answers in pen only 3. Make sure your exam has nine pages including this cover page Page 2 _______________ Page 3 _______________ Page 4 _______________ Page 5 _______________ Page 6 _______________ Page 7 _______________ Page 8 _______________ Page 9 _______________ Total _______________ Maximum of 100 points
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Name:___________________________________ ID:_________________________________ 2 A. It has been said that the accumulation of discarded unsuccessful experiments from the organic chemistry labs on the main campus into Roth Pond has led to the formation of a diversity of mutant species. Here are descriptions of the hemoglobins from some of these species. Using what you know about human hemoglobin A and recognizing that these are all mutant hemoglobins, indicate which property is most likely to be true for each of the mutant hemoglobins by circling the letter of the best answer. 1. This monomeric hemoglobin has its heme iron stabilized in the ferric (Fe +3 ) state. a. It is likely to bind oxygen with a low affinity hyperbolic saturation curve. b. It is likely to bind oxygen with a high affinity hyperbolic saturation curve. C . It is likely that this hemoglobin fails to bind oxygen at all. d. The oxygen binding curve for this hemoglobin will be hyperbolic but the information is insufficient to judge affinity. e. This hemoglobin will bind oxygen but will fail to undergo an oxygenation-linked conformational change. Oxygen, carbon monoxide, and nitric oxide are reversible ligands for the heme iron only when it is in the ferrous state. 2. This tetrameric mutant hemoglobin has a cavity into which pesticides can bind when the mutant protein is fully saturated with oxygen. The deoxygenated mutant protein fails to bind pesticides because the cavity is too small. The pesticides which are dumped into Roth Pond will probably: a. prevent the mutant protein from releasing oxygen. b. convert the oxygen binding curve to a hyperbolic curve without affecting the affinity of the protein for oxygen c. decrease the affinity of the mutant hemoglobin for oxygen but not necessarily eliminate sigmoidal oxygen binding. d. decrease both the affinity of the mutant hemoglobin for oxygen and the sigmoidicity of the oxygen binding curve. E . increase the affinity of the mutant hemoglobin for oxygen but not necessarily eliminate sigmoidal oxygen binding. Pesticides appear to bind only to the high affinity quaternary conformation in the manner of a positive allosteric effector. They should shift the oxygen binding curve to higher affinity but they might not eliminate the sigmoidal shape of the curve unless they were present at very high concentrations. 3. The model of cooperativity which best fits the behavior of the mutant hemoglobin in
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Exam2-2006Key - BIO 361 EXAM 2 FALL 2006 NAME:_KEY_ ID:_ 1....

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