Exam3-2007Key - _KEY_ Name (Last, First) BIO 361 _ SOLAR ID...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
______KEY ________________________ _____________________________________ Name (Last, First) SOLAR ID 1 BIO 361 EXAM 3 FALL 2007 NAME:_______KEY ______________________________________ ID:_____________________________________________________ 1. Write Your name and ID on all pages 2. Write all answers in pen only 3. Make sure your exam has 9 pages including this cover page Page 2 _______________ Page 3 _______________ Page 4 _______________ Page 5 _______________ Page 6 _______________ Page 7 _______________ Page 8 _______________ Page 9 _______________ Total _______________
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
______KEY ________________________ _____________________________________ Name (Last, First) SOLAR ID 2 1. Red blood cells do not contain mitochondria. a. Provide a balanced equation (substrates, products, cofactors) and the name of the enzyme that catalyzes the last reaction of glucose metabolism in red blood cells. Structures are NOT required. (4 points) Pyruvate + NADH + H + Lactate + NAD + (2 pts) Lactate dehydrogenase ( 2 pts) b. Why do red blood cells need to catalyze this last reaction? (2 points) To regenerate NAD + so that glycolysis can continue in the absence of mitochondria. 2. One of the most common genetic deficiencies in humans results in a hemolytic anemia induced by fava beans and anti-malarial compounds such as primaquine. a. Name the enzyme lacking in this deficiency. (2 points) Glucose 6-phosphate dehydrogenase b. Provide a balanced equation for the reaction catalyzed by this enzyme (substrates, products, cofactors). Provide names and structures for substrates and products, name only for cofactors. (4 points) (1 pt each structure, 2 pts balanced equation) c. Which of the products of this reaction is necessary to protect red blood cells from hemolytic anemia? (2 points) NADPH
Background image of page 2
______KEY ________________________ _____________________________________ Name (Last, First) SOLAR ID 3 3. Galactosemia results from a failure to metabolize galactose. a. Which enzyme is usually affected in patients with galactosemia? (2 points) Uridyltransferase (Galactose 1-phosphate uridyltransferase) b. What is the usual treatment for patients with galactosemia? (2 points) Remove galactose from diet (mainly milk products) 4. Beri-Beri is a neurological disorder caused by thiamine deficiency. a. Name three enzymes in humans that are affected by thiamine deficiency. (6 points) Pyruvate dehydrogenase α -Ketoglutarate dehydrogenase Transketolase b. Although each of these enzymes catalyzes a different reaction, thiamine pyrophosphate functions by stabilizing a common intermediate in each. What is the common intermediate, and how does thiamine pyrophosphate stabilize it? (2 points) Common intermediate: carbanion. Stabilize by resonance.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/19/2010 for the course BIO 361 taught by Professor Lake during the Fall '08 term at SUNY Stony Brook.

Page1 / 9

Exam3-2007Key - _KEY_ Name (Last, First) BIO 361 _ SOLAR ID...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online