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BIO 361 EXAM 4 AND CUMULATIVE FINAL FALL 2008 VERSION 1 NAME:_______________KEY _______________________________ ID:_____________________________________________________ INSTRUCTIONS FOR EXAM 4 (pages 2-7): 1. Write your name and ID on pages 1-7 2. Write all answers in pen only 3. Limit your answers to the space provided Page 2 _______________ Page 3 _______________ Page 4 _______________ Page 5 _______________ Page 6 _______________ Page 7 _______________ Total _______________ Maximum of 100 points INSTRUCTIONS FOR CUMULATIVE FINAL (pages 8-17) (100 points total): a. Answer all questions on the Opscan sheet. Only one answer per question. b. Use a number 2 pencil. c. Fill in NAME (LAST, FIRST, and MI), and IDENTIFICATION NUMBER (Solar ID number) using the bubbles. d. Fill in bubble “1” (for Version 1) in the first column under DAY (do not fill in the remainder of BIRTH DATE).
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______________________________ _____________________________________ Name (Last, First) SOLAR ID 2 1. Regarding fatty acid biosynthesis: a. Name and draw the structure of the final fatty acid product of mammalian fatty acid synthase. (2 points) CH 3 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -COO - Palmitate b. On the structure drawn above, circle the last two carbons added to this fatty acid. (2 points) c. How many of each of the following is required to synthesize the molecule shown above starting from Acetyl-CoA? (1 point each) __ 8 __ Acetyl-CoA __ 7 __ ATP __ 14 _ NADPH d. CO 2 participates in the reactions of fatty acid biosynthesis, but the carbon in CO 2 is not part of the fatty acid product. Explain why this is so. (3 points) The CO 2 is added to acetyl-CoA to make malonyl-CoA, but is lost during the condensation reaction (ß-ketoacyl-ACP synthase reaction). 2. For each of the following statements about cholesterol biosynthesis, fill in the blank with the most appropriate answer. (10 points total) a. Squalene is synthesized by condensation of two molecules of farnesyl pyrophosphate _______. b. HMG-CoA reductase reduces HMG-CoA to __ mevolonate ________________ and CoA. c. The major regulatory site of cholesterol biosynthesis is catalyzed by HMG-CoA reductase _________________. d. SCAP (SREBP cleavage-activating protein) contains a sterol-sensing domain. It remains in the endoplasmic reticulum when cholesterol is abundant, but moves to the Golgi when cholesterol levels drop. e. Genetic deficiency in the LDL receptor results in a disease known as
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