Lecture24-2010

Lecture24-2010 - 10/30/10 Preparatory Stage Glycolysis 2...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
10/30/10 1 Glycolysis 2 Lecture 24 Chapter 15, Sections 3 and 5 Figure 15-1 Preparatory Stage Payoff Stage Page 497 Reaction 6: GAP dehydrogenase Dehydrogenases: involved in oxididation/reduction reactions. Couples favorable oxidation to unfavorable phosphorylation through covalent intermediate: thioester Figure 15-9 GAP dehydrogenase mechanism
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10/30/10 2 Page 499 Reaction 7: Phosphoglycerate kinase Substrate level phosphorylation PGK catalyzes a coupled reaction Favorable hydrolysis of 1,3-BPG coupled to unfavorable phosphorylation of ADP 1,3-BPG + H 2 O -----> 3PG + Pi Δ G o ’ = -49.3 kJ/mol ADP + Pi -----> ATP + H 2 O Δ G o ’ = +30.5 kJ/mol _________________________________________________ 1,3-BPG + ADP -----> 3PG + ATP Δ G o ’ = -18.8 kJ/mol GAP + Pi + NAD + -----> 1,3-BPG + NADH + H + Δ G o ’ = +6.7 kJ/mol 1,3-BPG + ADP -----> 3PG + ATP Δ G o ’ = -18.8 kJ/mol _________________________________________________ GAP + Pi + ADP + NAD + -----> 3PG + ATP + NADH + H + Δ G o ’ = -12.1 kJ/mol 1,3-BPG is a common intermediate between an unfavorable and favorable reaction Figure 15-12 Reaction 8: Phosphoglycerate mutase Mutase: subclass of isomerases, moves functional group from one position to another on substrate.
Background image of page 2
10/30/10 3 Page 500 Where does phosphate come from? Priming reaction: 3PG kinase 3PG + ATP -------> 2,3-BPG + ADP Binds to PGM Page 500 Reaction 9: Enolase Reversible hydration/dehydration Page 501 Reaction 10: Pyruvate kinase
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/19/2010 for the course BIO 361 taught by Professor Lake during the Fall '08 term at SUNY Stony Brook.

Page1 / 10

Lecture24-2010 - 10/30/10 Preparatory Stage Glycolysis 2...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online