Lecture25-2010

Lecture25-2010 - Pyruvate Dehydrogenase Complex Lecture 25...

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Click to edit Master subtitle style Pyruvate Dehydrogenase Complex Lecture 25 Chapter 17-1, 17-2 Chapter 14-2D, 14-3A
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Figure 14-3 Overview of Catabolism (e-) 2 Pyruvates contain 95% of the potential energy in 1 glucose
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Figure 17-1 Catabolism converges on Acetyl- CoA Matrix of mitochondria
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Figure 18-2 Mitochondrion: Outer membrane: freely permeable to small molecules. Inner membrane: non-permeable. Transport requires transmembrane carriers that maintain charge state across membrane (antiporters).
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Figure 17-2
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Pyruvate Dehydrogenase Complex Balanced equation: Pyr + NAD+ + CoA --> Acetyl-CoA + CO2 + NADH Oxidative decarboxylation Irreversible: Go’ = -33.4 kJ/mole Note: cannot go back to glucose from Acetyl-CoA.
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Pyruvate Acetyl-CoA e- CO2 Citric Acid Cycle Fatty acids CO2 Pyruvate has multiple fates. Acetyl-CoA has two major fates.
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Pyruvate Dehydrogenase Complex Three enzymes with five cofactors E1: Pyruvate dehydrogenase (TPP) E2: Dihydrolipoyl transacetylase (Lipoamide,
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This note was uploaded on 11/19/2010 for the course BIO 361 taught by Professor Lake during the Fall '08 term at SUNY Stony Brook.

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Lecture25-2010 - Pyruvate Dehydrogenase Complex Lecture 25...

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