10_DM wrap up - N116A 2010 Pathophysiology& Consequences ◦ Acute effects of insulin deficiency(effects on C P& F metabolism ◦ Long term

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: N116A 2010 Pathophysiology & Consequences ◦ Acute effects of insulin deficiency (effects on C, P & F metabolism) ◦ Long term complications Clinical Trials in Diabetes & implications for Nutrition ◦ DCCT & EDIC ◦ DPP & DPPOS, ACCORD MNT Goals & Recommendations Type 1 Diabetes ◦ Autoimmune disease – absence of insulin production Impaired Glucose Tolerance– “Pre-Diabetes” ◦ Variable etiology ◦ Decreased ability to regulate blood glucose Type 2 Diabetes ◦ Relative lack of insulin, and decreased or lack of response to insulin at tissues Gestational Diabetes – DM developing during pregnancy Fig 17.10 in Text Grouped according to macronutrient substrate metabolism (C, P, F) Insulin deficiency, whether absolute (as in Type 1 DM) or relative (as in Type 2 DM), results in signs and symptoms ◦ Polyuria, polyphagia, polydipsia, ◦ And also include others such as: ketosis, wt loss, etc. Understand the metabolic pathophysiology behind the clinical manifestations Limited/or No glucose uptake by cells → ◦ ↓ intracellular glucose → polyphagia ◦ Glucagon stimulates ↑ hepatic glucose output → hyperglycemia → glucosuria occurs when renal threshold for glucose is exceeded → osmotic diuresis → therefore polyuria occurs → → dehydration leads to polydipsia ◦ Cellular dehydration & shrinking (hyperglycemic, hyperosmolar syndrome) → nervous system malfunction (irritability, fatigue, blurred vision) ◦ If polyuria is unable to be corrected → low blood volume → circulatory failure to periphery, kidneys, brain, etc… death possible ↓ TG synthesis, ↑ lipolysis due to counterregulatory...
View Full Document

This note was uploaded on 11/21/2010 for the course NUT 116A 72876 taught by Professor Steinberg/stern during the Fall '10 term at UC Davis.

Page1 / 23

10_DM wrap up - N116A 2010 Pathophysiology& Consequences ◦ Acute effects of insulin deficiency(effects on C P& F metabolism ◦ Long term

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online