A_10%20Immunology_3%20per%20pg%20color

A_10%20Immunology_3%20per%20pg%20color - 1 Immunology,...

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Unformatted text preview: 1 Immunology, Nutrition and Disease Review of basic concepts in immunology Nutrition/nutrients and the immune system Examples of nutrition and immune function in chronic disease Food Allergies Why do we have an immune system? To protect us against potentially deadly infection Infectious diseases have been a major selective pressure in human evolution malaria Plague Why do we care about nutrition and the Malnutrition impairs immune function and slows recovery from infections protein-energy malnutrition (e.g., anorexia) vitamin deficiencies (e.g., A, D) mineral deficiencies (e.g., zinc, iron) Inflammation can adversely impact nutritional status Inflammation can affect the biochemical indicators of nutritional status immune system? Does the immune system have a role in chronic disease? Cancer yes, chronic inflammation (e.g., hepatitis B virus) can cause cancer yes, cytotoxic T cells and NK cells can identify and kill some types of cancer cells Heart disease yes, inflammation mediated by macrophages may exacerbate arterial lesions that cause heart attacks diet can help to ameliorate this adverse effect Arthritis yes, inflammation mediated by antibody and neutrophils destroys cartilage and bone diet can ameliorate this adverse effect to some extent 2 Inflammatory Conditions with Nutrition Implications Gut injury Inflammatory bowel disease Wounds/trauma Sepsis/adult respiratory distress syndrome Organ failure (heart, lung, liver, kidney) Obesity Cardiovascular disease Diabetes HIV/AIDS Cancer Trauma, infection or disease Immune Activation Anti-inflammatory vs Pro-inflammatory cytokines Mobilization of nutrients Loss of body mass Tissue damage Adverse outcomes Organization of Immune System Primary organs bone marrow origin of lymphocytes, granulocytes thymus education of T cells self-reacting T cel s deleted in thymus to prevent autoimmunity Secondary organs spleen lymph nodes (LN) Lymphatic system brings antigen to LN to sensitize lymphocytes Essential Concepts in Immunology. Weissman, Hood, Wood. Foundations of the Immune System Organs of the Immune System- originate from stem cells Central Bone marrow, thymus Peripheral Lymphatic system/ lymph Spleen MALT BALT GALT Peyers Patches 3 Fig. 9-6, p. 160 Innate and Adaptive Immunity Innate (Cellular) Immunity First line of defense requires no previous exposure of individual to a particular pathogen Barrier Defenses Adaptive (Humoral) Immunity first exposure creates memory second exposure more rapid response cells involved Skin, conjunctiva, respiratory, GI, urogenital tracts Includes pH, mucus, lysozymes Phagocytic cells macrophages granulocytes Inflammation local systemic (acute phase response) cells involved...
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This note was uploaded on 11/21/2010 for the course NUT 116A 72876 taught by Professor Steinberg/stern during the Fall '10 term at UC Davis.

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A_10%20Immunology_3%20per%20pg%20color - 1 Immunology,...

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