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Unformatted text preview: 9/26/2010 1 N 116A Nutrigenomics Introduction Nutritional Phenotype Nutritional Phenotype Medicine Genes Diet Environment Behavior Nutritional Phenotype Nutritional Phenotype Medicine Genes Diet Environment Behavior Oxidative Stress Metabolic Stress Psychological Stress Inflammatory Stress Nutrigenomics The study of how dietary choices & food components affect the human physiologic system, from the genome (genetics) level, to proteome (proteins), to metabolome (metabolites), and ultimately physiologic functioning and health. Underlying assumptions : Diet & dietary components can alter risk of disease development by modifying processes involved with onset, progression or severity Food components can act on the human genome directly, or indirectly at levels of protein expression & function, to alter expression of genes and gene products Diet can potentially compensate for or accentuate effects of genetic polymorphisms GOAL: Personalized nutrition therapies to maximize genetic potentials, prevent chronic disease and improve treatment outcomes Scheme of the potential of genetics, nutrigenetics and pharmacogenetics in health maintenance and treatment of diseases Proc Nutr Soc 2009 68:162-172 Rimbach & Minihane Nutrigenomics Nutrigenomics Interaction between nutrients and genotype Genetic Variants can determine individual response to dietary factorspropensity to develop disease Diets and Genes influence Health and Disease More than just diet can interact with genotype As an example: Pharmacogenomics Genotype X Environment Interactions Different effects of environmental exposure on disease risk in persons with different genotypes 9/26/2010 2 Nutrigenomics Analyzing the effects of diet on the activity of an individuals genes and health and the effect of an individuals genes on metabolism of dietary chemicals Diet = nutritional science Genes, Cellular metabolism = genetics, molecular biology, biochemistry Health = physiology Systems Biology sciencemultidisciplinary and integrative What is Nutritional Genomics?...
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This note was uploaded on 11/21/2010 for the course NUT 116A 72876 taught by Professor Steinberg/stern during the Fall '10 term at UC Davis.
- Fall '10