A_10_phyto%20lect

A_10_phyto lect - 1 Emerging Nutrients – Phytochemicals NUT 116A Fall 2010 “ Let food be thy Let food be thy medicine and medicine medicine and

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Unformatted text preview: 1 Emerging Nutrients – Phytochemicals NUT 116A Fall 2010 “ Let food be thy Let food be thy medicine and medicine medicine and medicine be thy food” be thy food” Hippocrates Hippocrates The Father of Medicine The Father of Medicine 460 BC 460 BC – 377 BC 377 BC Complementing the desire for Complementing the desire for “optimal health”, “optimal health”, the public is embracing the the public is embracing the concept of concept of ----“food as medicine” “food as medicine” in response to the evolving in response to the evolving health care crisis that is health care crisis that is occurring in most occurring in most developed countries developed countries Fruits and Vegetables Decrease Cardiovascular Disease Risk Multivariate adjusted* RR for >=3 times/day vs. <1 time/day- Ischemic heart disease Ischemic heart disease mortality RR=0.76 (95% CI: mortality RR=0.76 (95% CI: 0.56, 1.03) 0.56, 1.03)- CVD mortality RR=0.73 (95% CVD mortality RR=0.73 (95% CI: 0.58, 0.92) CI: 0.58, 0.92)- All cause mortality RR=0.85 All cause mortality RR=0.85 (95% CI: 0.72, 1.00) (95% CI: 0.72, 1.00) * adjusted for age, sex, race, energy, adjusted for age, sex, race, energy, physical activity, alcohol consumption, physical activity, alcohol consumption, smoking, plus others smoking, plus others Bazzano et al AJCN 2002; 76, 93-99 Relationship Between CHD Death Rate and Dairy Relationship Between CHD Death Rate and Dairy Fat Consumption Fat Consumption “The French Paradox” “The French Paradox” Flavanoids and CVD Health: Red Wine Flavanoids and CVD Health: Red Wine Renaud Renaud-S, de Lorgeril, M. S, de Lorgeril, M. Lancet Lancet 1992; 339:1523 1992; 339:1523-1526 1526 Flavonoid Intake and Risk of CHD Mortality 20 20 25 25 30 30 35 35 CHD Mortality, %CHD Mortality, % 5 10 10 15 15 1 10 20 20 30 30 40 40 50 50 60 60 70 70 80 80 Mean Flavonoid Intake (mg/day) Mean Flavonoid Intake (mg/day) AgeAge-Adjusted Adjusted Hertog et al. Arch Intern Med 155: 381-386, 1995 2 Flavonoids, Flavonoid-rich Foods & Chronic Disease Risk • AJCN 2008 Hooper et al. – Meta-Analysis of 133 RCT on various flavonoid food sources on CVD risk – Green tea ( LDL), cocoa ( FMD), soy protein ( LDL) – Clinically relevant changes observed • AJCN 2007 Mink et al. – Flavonoids and CVD mortality in Iowa Women’s Health Study – Found RR for highest vs lowest quintile or any intake vs none for classes of flavonoids between 0.78 and 0.91 – Individual foods associated w/ risk reduction included bran, apples, pears, red wine, grapefruit, strawberries, chocolate • Int J Cancer 2008 Cutler et al. – Flavonoids and Cancer Risk in Iowa Women’s Health Study – Isoflavone intake inversely associated w/ overall cancer incidence – Lung cancer incidence inversely associated w/ flavanones & proanthocyanins. Strongest effect in current & past smokers Comments on Epidemiologic vs Clinical Trials for Investigation Flavonoids • Observational Epidemiologic studies can confirm or negate...
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This note was uploaded on 11/21/2010 for the course NUT 116A 72876 taught by Professor Steinberg/stern during the Fall '10 term at UC Davis.

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A_10_phyto lect - 1 Emerging Nutrients – Phytochemicals NUT 116A Fall 2010 “ Let food be thy Let food be thy medicine and medicine medicine and

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