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Unformatted text preview: The Journal of Nutrition Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Human Plasma Levels of Vitamin E and Carotenoids Are Associated with Genetic Polymorphisms in Genes Involved in Lipid Metabolism 1–3 Patrick Borel, 4 * Myriam Moussa, 4 Emmanuelle Reboul, 4 Bernard Lyan, 5 Catherine Defoort, 4 Ste ´phanie Vincent-Baudry, 4 Matthieu Maillot, 4 Marguerite Gastaldi, 4 Michel Darmon, 4 Henri Portugal, 4 Richard Planells, 4 and Denis Lairon 4 4 INSERM, U476 ‘‘Nutrition Humaine et Lipides’’, INRA, UMR1260, and Univ Me ´diterrane ´e Aix-Marseille 2, Faculte ´ de Me ´decine, IPHM-IFR 125, Marseille, F-13385 France; and 5 INRA, UMR1019 ‘‘Nutrition Humaine’’, Saint-Genes-Champanelle, F-63122 France Abstract Vitamin E and carotenoids are fat-soluble micronutrients carried by plasma lipoproteins. Their plasma concentrations are governedbyseveralfactors,someofwhicharegenetic,butdataonthesegeneticfactorsremainscarce.Wehypothesizedthat genes involved in lipid metabolism, i.e. the genes implicated in intestinal uptake, intracellular trafficking, and the lipoprotein distribution of lipids, play a role in the plasma concentrations of these micronutrients. To verify this hypothesis, we assessed whether the plasma status of vitamin E and carotenoids is related to genes involved in lipid metabolism. Fasting plasma vita- min E ( a- and g-tocopherol) and carotenoid ( a- and b-carotene, lutein, lycopene, b-cryptoxanthin, and zeaxanthin) concen- trations were measured in 48 males and 80 females. The following genes were genotyped [single nucleotide polymorphisms (SNP)]: apolipoprotein (apo) A-IV, apo B, apo E, lipoprotein lipase, and scavenger-receptor class B type I (SR-BI). Plasma a-tocopherol concentrations were different ( P , 0.05) in subjects bearing different SNP in apo A-IV, apo E, and SR-BI. Plasma g-tocopherol concentrations were different ( P , 0.05) in subjects bearing different SNP in apo A-IV and SR-BI. a-Carotene concentrations were different ( P , 0.05) in subjects bearing different SNP in SR-BI. b-Carotene concentrations were different ( P , 0.05) in subjects bearing different SNP in apo B and SR-BI. Lycopene concentrations were different ( P , 0.05) in subjects bearing different SNP in apo A-IV and apo B. b-Cryptoxanthin concentrations were different ( P , 0.05) in subjects bearing different SNP in SR-BI. Plasma lutein and zeaxanthin concentrations did not differ in subjects bearing different SNP. Most of the differences remained significant after the plasma micronutrients were adjusted for plasma triglycerides and cho- lesterol. These results suggest that genes involved in lipid metabolism influence the plasma concentrations of these fat-soluble micronutrients. J. Nutr. 137: 2653–2659, 2007....
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- Fall '10
- Plasma, Vitamin E, High-density lipoprotein, Apolipoprotein E