Borel - The Journal of Nutrition Nutrient Physiology,...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: The Journal of Nutrition Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Human Plasma Levels of Vitamin E and Carotenoids Are Associated with Genetic Polymorphisms in Genes Involved in Lipid Metabolism 1–3 Patrick Borel, 4 * Myriam Moussa, 4 Emmanuelle Reboul, 4 Bernard Lyan, 5 Catherine Defoort, 4 Ste ´phanie Vincent-Baudry, 4 Matthieu Maillot, 4 Marguerite Gastaldi, 4 Michel Darmon, 4 Henri Portugal, 4 Richard Planells, 4 and Denis Lairon 4 4 INSERM, U476 ‘‘Nutrition Humaine et Lipides’’, INRA, UMR1260, and Univ Me ´diterrane ´e Aix-Marseille 2, Faculte ´ de Me ´decine, IPHM-IFR 125, Marseille, F-13385 France; and 5 INRA, UMR1019 ‘‘Nutrition Humaine’’, Saint-Genes-Champanelle, F-63122 France Abstract Vitamin E and carotenoids are fat-soluble micronutrients carried by plasma lipoproteins. Their plasma concentrations are governedbyseveralfactors,someofwhicharegenetic,butdataonthesegeneticfactorsremainscarce.Wehypothesizedthat genes involved in lipid metabolism, i.e. the genes implicated in intestinal uptake, intracellular trafficking, and the lipoprotein distribution of lipids, play a role in the plasma concentrations of these micronutrients. To verify this hypothesis, we assessed whether the plasma status of vitamin E and carotenoids is related to genes involved in lipid metabolism. Fasting plasma vita- min E ( a- and g-tocopherol) and carotenoid ( a- and b-carotene, lutein, lycopene, b-cryptoxanthin, and zeaxanthin) concen- trations were measured in 48 males and 80 females. The following genes were genotyped [single nucleotide polymorphisms (SNP)]: apolipoprotein (apo) A-IV, apo B, apo E, lipoprotein lipase, and scavenger-receptor class B type I (SR-BI). Plasma a-tocopherol concentrations were different ( P , 0.05) in subjects bearing different SNP in apo A-IV, apo E, and SR-BI. Plasma g-tocopherol concentrations were different ( P , 0.05) in subjects bearing different SNP in apo A-IV and SR-BI. a-Carotene concentrations were different ( P , 0.05) in subjects bearing different SNP in SR-BI. b-Carotene concentrations were different ( P , 0.05) in subjects bearing different SNP in apo B and SR-BI. Lycopene concentrations were different ( P , 0.05) in subjects bearing different SNP in apo A-IV and apo B. b-Cryptoxanthin concentrations were different ( P , 0.05) in subjects bearing different SNP in SR-BI. Plasma lutein and zeaxanthin concentrations did not differ in subjects bearing different SNP. Most of the differences remained significant after the plasma micronutrients were adjusted for plasma triglycerides and cho- lesterol. These results suggest that genes involved in lipid metabolism influence the plasma concentrations of these fat-soluble micronutrients. J. Nutr. 137: 2653–2659, 2007....
View Full Document

This note was uploaded on 11/21/2010 for the course NUT 72880 taught by Professor Clifford during the Fall '10 term at UC Davis.

Page1 / 7

Borel - The Journal of Nutrition Nutrient Physiology,...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online