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Bio Lecture 13 - Reading and study guide for Lecture 18...

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Reading and study guide for Lecture 18 Required reading Chapter 12, pgs. 238-243 Chapter 18.5, pgs. 373-377 Pre-Lecture Quiz
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Overview of today’s lecture: cell cycle checkpoints how are they regulated at the molecular level how do viruses take control of the cell cycle how a virus called HPV causes cervical cancer HeLa cells…….
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Cell cycle checkpoints
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Protein kinases and cyclins: regulatory molecules Protein kinases give go-ahead signals at G1 and G2 checkpoints To be active, protein kinase must be attached to a cyclin Thus, they are known as cyclin-dependent kinases, or Cdks
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Molecular mechanism that helps regulate the cell cycle:
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Getting to know a cancer cell: hallmark characteristics
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The growth and metastasis of a malignant breast tumor
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VIRUS HIV Cowpea mosaic Virus SV40 Dengue virus Bluetongue virus Rhinovirus (cold)
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How research on viruses led to discovery of genes that control cell growth and division: In 1910, a farmer from New York visited Peyton Rous at the Rockefeller Institute and showed him a hen with a large solid tumor.
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