Lecture 21 - Bio 93 Fall 2009 Lecture 21 Regulation of gene...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Reading: Chapter 18, pages 356-366 Bio 93 Fall 2009 Lecture 21 Regulation of gene expression Monday 11/16/09
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Differences between most cell types are due not to different genes in those cells, but to differential gene expression How does differential gene expression occur? Each stage is a potential control point for gene expression and ultimately protein function
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Regulation level: transcription Chromatin (the protein/DNA complex that packs a cell’s DNA into the nucleus also provides critical regulation of gene expression Histone tails are subject to Modification (e.g. acetylation) that plays a direct Role in regulating the expression of genes
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What can an understanding of gene expression via histone modification be used for?
Background image of page 6
Short-term memory (minutes to hours) Long-term memory (hours to days, even a lifetime!) Transcription Gene expression is necessary for long-term Memory formation To understand the molecular mechanisms underlying long- term memory formation
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Histone acetyltransferases (HATs) CREB-binding protein (CBP) Genes off Genes on
Background image of page 8
HDACs What if we make accessing genes easier? X
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/19/2010 for the course BIOLOGY 93 taught by Professor O during the Spring '08 term at San Diego.

Page1 / 25

Lecture 21 - Bio 93 Fall 2009 Lecture 21 Regulation of gene...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online