stat530hw2 - STAT530 Homework 2 Due: October 3rd Download...

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STAT530 Homework 2 Due: October 3 rd Download the schizophrenic data from course website (schizophrenia.xls: 7072 probe sets, 24 samples). This dataset is a matrix of the estimated expression values from the postmortem dorsolateral prefrontal cortex of 12 control and 12 schizophrenic patients (Hakak, 2001). Affymetrix HuGeneFL chips, which are oligonucleotide mRNA chips, were used and a model-based method is used to calculate the expression intensities for each probe set in samples. For this homework, replace any negative expression value with zero. 1. [Use R, Excel or SAM software for this problem] Perform the following genewise comparisons to find top 200 genes that are mostly differentially expressed in two groups (control vs schizophrenic patients). Order these 200 genes from the ones most up-regulated in schizophrenic patients to most down regulated ones. Present them in heatmap diagrams. (1) Fold change
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This note was uploaded on 11/21/2010 for the course STAT STAT530 taught by Professor Ma during the Spring '07 term at University of Illinois, Urbana Champaign.

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stat530hw2 - STAT530 Homework 2 Due: October 3rd Download...

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