Lecture 5 - Summary 1. 2. 3. 4. 5. 6. 7. Membranes are made...

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Summary 1. Membranes are made of lipids and proteins; 2. Lipid bilayer is a energetically favored structure; 3. Fluidity, permeability and asymmetry of lipid bilayer 4. Membrane proteins and transmembrane domains; 5. Membrane protein modifications and asymmetry; 6. RBCs are good models for plasma membrane; 7. Membrane proteins in some membranes are more free to move laterally; 8. Carbohydrate layer. This week’s office hour will be from 2:00-3:00 pm Friday
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Lecture 5: Membrane Transport of Small Molecules and Electrical Properties
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The relative permeability of a synthetic lipid bilayer
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Ion concentrations inside and outside the cells are often different
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Two main classes of membrane transport proteins Both: Specificity Multi-TM Hydrophilic solutes cross membrane via hydrophilic protein pathway transporters (aka carriers, permeases) Conformation change Aqueous Pores (faster) Requires binding! Can move to higher concentration Passive diffusion! High con to low con
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Passive transport, active transport, electrochemical gradient
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Reversible conformational change in a carrier protein
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Like an enzyme reaction--it saturates (affinity)
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Three ways of driving active transport bacteriorhodopsin
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Three types of transporter-mediated movement Primary active transport: ATP-driven Secondary active transport: ion-driven Na + is the usual co-transported ion
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Lecture 5 - Summary 1. 2. 3. 4. 5. 6. 7. Membranes are made...

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