Lecture 7 - Summary 1. Cells are highly compartmentalized;...

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Summary 1. Cells are highly compartmentalized; proteins are sorted to different compartments; 1. Nuclear transport, nuclear pore, nucleoporins, NLS; 2. Ran GTPase control direction; 3. Nuclear lamina, nuclear lamins; 4. Mitochondria transport, signal sequence, TOM, TIM, energy; 1. Chloroplast transport, thylakoid; 2. Peroxisomes, structure, function, transport, biogenesis.
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Lecture 7 Endoplasmic reticulum: protein synthesis and modification, lipid synthesis
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All eukaryotic cells have an ER, more than half the total membrane ER lumen or ER cisternal space: one continuous space 10% of the total cell volume Protein and lipid synthesis Both transmembrane and water soluble proteins are synthesized and translocated across the ER membrane mammalian cell plant cell
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The rough ER Co-translational process for secreted or membrane proteins: no chaperones are required, import before complete synthesis
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Free and membrane-bound ribosomes
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Smooth ER is abundant in some specialized cells In most cells: partly smooth, partly rough
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Lecture 7 - Summary 1. Cells are highly compartmentalized;...

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