Lecture 9 - Summary 1. Vesicular transport,...

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Summary 1. Vesicular transport, biosynthetic-secretory and endocytic pathways; 2. Coated vesicles; 1. Coat assembly and disassembly, budding, dynamin, coat-recruitment GTPases; 1. Targeting and fusion by Rab GTPases, SNAREs; 2. ER to Golgi: COPII, folding, fusion (cluster), retrograde; 3. Golgi apparatus structure and polarity; 4. Continuation of glycosylation; 5. Compartmentalization of Golgi cisternae; 6. By now we have introduced gated transport, transmembrane transport and vesicular transport.
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Lecture 9 Vesicular Transport: From the trans Golgi to lysosomes; endocytosis and exocytosis
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pH is one of the mechanisms for protecting contents in the cytosol Vacuolar H + ATPase: Lysosomes (pH 4.5-5.0) Vacuolar H + ATPase: also present in Endosomes Selected compartments of Golgi Apparatus Transport vesicles Secretory vesicles All major classes of macromolecules are degraded in lysosomes Lysosomal glycoproteins are unusually highly glycosylated (protection) 40 hydrolytic enzymes
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Lysosomes are highly heterogeneous Shape and size (reflect diverse function or how they form) But all have acid hydrolases The “stomach” of a cell Stained for acid phosphatase: precipitate formed by a phosphatase substrate in the presence of lead ion
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Huge vacuoles of plant cells Related to lysosomes Storage organelle Degradative compartments Turgor pressure (prevent wilting) Homeostatic device (pH, osmotic pressure) Rubber Opium Garlic Proteins Pigments Noxious molecules
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Lecture 9 - Summary 1. Vesicular transport,...

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