Lecture 12 - Summary 1. Cell communication is essential for...

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Summary 1. Cell communication is essential for both mutlicellular organism and unicellular organisms; 1. Different forms of signaling, different signal molecules, receptors; 2. Switches, intracellular signaling proteins, complexes, integration 3. Non-linear responses; 4. Regulation of signal sensitivity
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Lecture 12 Cytoskeleton: components
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The cytoskeleton Cytoskeleton: filament system Internal order Shape and remodel surface Move organelles Movement Cell division Three types of filaments and accessory proteins (assembly of cytoskeleton, motor proteins that move organelles or filaments) Two components are shown: microtubules (green) and actin (red)
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Intermediate filaments: mechanical strength and resistance to shear stress Microtubules: positions of membrane- enclosed organelles, intracellular transport Actin filaments: shape of the cell’s surface and whole cell locomotion Dynamic and adaptable 5-9 nm diameter 25 nm diameter 10 nm diameter
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Cytoskeletal filaments are all constructed from smaller protein subunits Intermediate filaments: smaller elongated and fibrous subunits Actin and microtubule filaments: compact and globular subunits All form as helical assemblies of subunits Noncovalent interactions: rapid assembly and disassembly (a lot slower for intermediate filaments)
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Ends are dynamic
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Lecture 12 - Summary 1. Cell communication is essential for...

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