Week_9_Pre-Discussion_Assignment - Erythropoietin The human...

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Erythropoietin The human growth hormone erythropoietin (EPO) is secreted primarily by the kidneys. It binds to receptors located on the surface of precursor cells in bone marrow that develop into red blood cells. In doing so, it protects the precursor cells from premature death or failure to mature. Patients with chronic kidney disease often develop a deficiency of red blood cells, or anemia , the symptoms of which include general weakness, fatigue, and in some cases serious heart problems. Many cancer patients also suffer from anemia following chemotherapy or bone-marrow transplantation. Many premature infants with a birth weight of 750 g to about 1500 g also tend to be anemic. Neonates weighing less than 1000 g need blood transfusions during the first week of life, in many cases every two or three days. In fact, the only available method of treating anemia has been the transfusion of blood from other individuals. But this exposes the patient, who is often immunologically compromised, to
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This note was uploaded on 11/22/2010 for the course CHEMISTRY Chem 1LB taught by Professor Dr.kimberlyedwards during the Fall '10 term at UC Irvine.

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Week_9_Pre-Discussion_Assignment - Erythropoietin The human...

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