chapter 16 outline 2 - Overview Nucleic acids direct their...

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Overview Nucleic acids direct their own replication from monomers Watson and Crick- structure of DNA DNA is the Genetic Material T.H. Mogan -> Genes (composed of protein and DNA) are located on chromosomes… either DNA or protein is responsible for the genetic material o Protein- specificity of function and great heterogeneity (thought it was the genetic material) o DNA- uniform physical and chemical properties Griffith- evidence that DNA can transform bacteria o Studied two strains of Streptococcus pneumoniae - pathogenic (Smooth S strain that has a capsule that protects it from the animal’s defense system) and nonpathogenic (Rough R strain that lacks the capsule) o Injected strains into mice: Living S cells (control) -> mouse dies Living R cells (control) -> mouse lives Heat killed S cells -> mouse lives Heat killed S cells mixed with living R cells -> mouse dies and has living S cells in blood sample. Also, descendants of this mouse inherited this pathogenicity (transformation)
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