Lecture+notes+06 - Copy - Lecture Notes Bio 109 Fall 2010...

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Lecture Notes Bio 109, Fall 2010, Dr. Catherine Loudon Lecture 6 – 10/06/10 – Hormones 1) Your question – How does a peptide hormone cross the membranes of the capillary endothelium (Fig. 7-3)? a) Answer – transcytosis (vesicular transport) (see Fig. 5-24) 2) Peptide hormones – characteristics (see Table 7.1) a) Most common class b) Water soluble (transported in blood) c) Don't enter cells d) Half-life usually minutes 3) Steroid hormones – characteristics a) Derived from cholesterol (Fig. 7-6) so similar chemical structures b) Made in adrenal glands, gonads c) Not stored (lipophilic) d) Transported in blood by carrier molecules e) Half-life of an hour to hours f) Interaction with target cells – usually cross into cytoplasm or nucleus (Fig. 7-7) 4) Amino-acid derived hormones a) Fewer types, fewer source organs (Fig. 7-8) b) Thyroid hormones contain iodine c) Properties like peptide or steroid hormones (Table 7-1) 5) Insulin – example of hormone a) Peptide b) Synthesized and released by pancreas c) Affects glucose metabolism d)
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  • Spring '10
  • CatherineLoudin
  • Physiology, Membranes, Dr. Catherine Loudon, Lecture Notes Bio, pancreas beta cells

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