Lecture+notes+08 - Copy - Lecture Notes Bio 109 Fall 2010...

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Lecture Notes Bio 109, Fall 2010, Dr. Catherine Loudon Lecture 8 – 10/11/10 – Action potentials, refractory periods 1) Announcements a) Extra office hour on Tuesday (so will be 8:30 am – 10:30 am instead of 9-10 am) b) Reminder – test 1 is on Friday (need #2 pencil and id); no electronic devices, scantrons will be provided 2) Reviewed quiz 1 question on the Nernst equation 3) Graded potentials and action potentials - a) Nernst equation (one ion) vs. Goldman-Hodgkin-Katz (for calculating membrane potential) b) Table 8-3 – understand differences between graded potential and action potentials 4) Electrical concepts that cause difficulties for some students a) May assume that ion concentrations do not change appreciably as equilibrium approached or reached. i) "A significant change in membrane potential requires the movement of very few ions .... To change the membrane potential by 100 mV, only one out of every 100,000 K+ must enter or leave the cell. This is such a tiny fraction of the total number of K+ ions in the cell that the concentration gradient for K+ remains essentially unchanged."
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