Lecture+notes+23 - Copy - Lecture Notes Bio 109 Fall 2010...

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Lecture Notes Bio 109, Fall 2010, Dr. Catherine Loudon Lecture 23 – 11/19/10 – Fluids, Digestive system 1) Spent more time on water/solute whole body diagrams a) Because urine may only be produced in range of 50-1200 mOsM, body may not be able to bring body back to target volume and osmolarity with some perturbations b) Seawater is 2000 mOsM, so drinking seawater will actually lead to dehydration (and increasing osmolarity) [clicker question in 11 am section, any answer counts] 2) Mechanism for production of hypo- and hyper-osmotic urine a) Recall that final urine is in range 50-1200 mOsM (depends on body osmolarity and water balance) (Fig. 20-4) b) Final adjustment of urine osmolarity takes place at the end (primarily collecting duct) c) Osmotic gradient in medulla (Fig. 20-4) (maintained by blood flow pattern) d) Descending limb of loop of Henle is permeable to water (so water moves out) e) Ascending arm of loop of Henle is impermeable to water, so water does not move out or in as ions are transported out of lumen of nephron f)
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