class_16_2010_notes - IB35ac Human Biological Variation...

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Unformatted text preview: IB35ac Human Biological Variation 10/18/2010 Copyright Prof. L.J. Hlusko 1 IB35 Human Biological Variation Class #16 Topics for today: Blood & Disease How disease has affected the pattern of human variation Topics for Today Founders & affected phenotypes Sickle cell anemia ABO blood types Worldwide causes of death TB HIV Respiratory Infections Malaria Other infections Respiratory disease Digestive diseases Other diseases Injuries Other Cancer Diabetes Heart Disease Stroke disease What is a founder ? A person who has a mutation that is then passed down through generations. Everyone with the mutation is related they have it in common because they are they have it in common because they are identical by descent. What is an affected phenotype ? IB35ac Human Biological Variation 10/18/2010 Copyright Prof. L.J. Hlusko 2 Symptoms:-- abnormally shaped red blood cells local tissue death Sickle Cell Anemia-- local tissue death-- skin lesions infection-- episodes of excruciating pain-- greatly reduced lifespan What causes RBCs to sickle? Missense mutation = abnormal hemoglobin HbS hemoglobin What causes RBCs to sickle? crystallizes into long rods within RBCs when deoxygenated. How is sickle cell anemia inherited?...
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class_16_2010_notes - IB35ac Human Biological Variation...

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