Bio Lecture October 18

Bio Lecture October 18 - O ctober 18 th , 2010 Types of...

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October 18 th , 2010 Types of mutations Spontaneous mutation DNA polymerase errors (mismatch repair- normal bases) Base mismatch (point mutation) Repeat slippage (insertion, deletions): repeats get things added or taken away from them like a frame shift Chemical (base excision repair BER- abnormal bases) Hydrolytic cleavage Oxidative damage Alkylation Induces mutation Chemical Alkylation Radiation (nucleotide excision repair NER) UV, x-ray, gamma rays Spontaneous mutation DNA polymerase w/o proofreading: 1 per 1 million bp errors w/ proofreading: 1 per 108 bp errors when the mismatch occurs the mismatched base is wobbly and unstable to difficult to add more bases stall repeat slippage: 1 slip per 10 6 – 10 7 repeats shifted by 2, 4, 6 bps chemical hydrolytic cleavage 1 mutation per 105 bp per division: relatively frequent (N glycolylic cleavage)
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1 mutation per 107 bp per division (deamination)
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This note was uploaded on 11/26/2010 for the course BIO 101 taught by Professor Rytasvilgalys during the Spring '09 term at Duke.

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Bio Lecture October 18 - O ctober 18 th , 2010 Types of...

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