HIST Quiz 1 notes - Quiz 1 \u2013 Histology Organelles For each organelle know function structure appearance on LM and EM Understand how cellular

HIST Quiz 1 notes - Quiz 1 u2013 Histology Organelles...

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Quiz 1 – Histology Organelles - For each organelle know function, structure, appearance on LM and EM - Understand how cellular function and subcellular components are related (i.e depending what organelles are in a cell what could be the function of the cell?) Organelle Function Appearance Relation b/w Cell Function & Organelle Nucleus Contains genetic material as heterochromatin (tightly bound = more e- dense = darker) & euchromatin (loosely bound = less e- dense = lighter) Bidirectional RNA & protein transport through nuclear pore Nucleus appears as purple/blue on LM - Only organelle consistently seen, the nucleolus will be darker - Heterochromatin = darker H&E = more basophilic, EM = more e- dense - Euchromatin = lighter, H&E = less basophilic, EM = less e- dense RER Synthesis of secreted proteins (on ribosomes) & membrane proteins – continuous with nuclear membrane Rough = ribosomes H&E stains blue b/c basophilic (-) charge from the ribosomes + RNA EM – series of flattened membranes dotted with dark grey ribosomes Cell with a large RER = a cell that produces a lot of proteins Ex. exocrine pancreatic cells SER Synthesis of cell membrane components, steroid hormones, detox enzymes, Continuous with RER but no ribosomes (smooth) – flattened/tubular sac- like Cells with prominent SER roles: detoxification (detoxification enzymes located in SER)ex liver cells, production of hormones ex. adrenal gland
glycogen metabolism, sequestration and release of Ca EM – appears as white blobs LM – pink net like structure (eosinophilic b/c of (+) proteins) Golgi CIS Golgi closest to RER TRANS Golgi furthest from RER Material enters cis and exits trans Glycosylation of membrane proteins & protein sorting Stack of flattened membrane sacks LM – appears as clear area in the cell EM – Flattened stack Cells with prominent Golgi are specialized to produce a lot of proteins (ex. plasma cells – produce antibodies (protein)

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