BME 314 Lecture 14 2010

BME 314 Lecture 14 2010 - BioelectricPhenomenaII Krish Roy,...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Bioelectric Phenomena II Krish Roy, PhD Associate Professor Biomedical Engineering
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Learning Objectives At the end of this lecture you should be able: Describe Donan equilibrium Solve ion concentration problems across membranes at Donan equilibrium Discuss the Goldman-Hodgkin-Katz equation Explain simplified models of cells as electrical circuits Solve membrane potential problems using electrical equivalent cell models
Background image of page 2
Donnan Equilibrium A typical cell is permeable to multiple ions (e.g., K+, Na+, Cl- for the neuron). The Nernst potential for each ion in a cell can be computed individually. However, the membrane potential of the cell is due to the presence of all the ions. Suppose a membrane is permeable to only 2 ions (K+ and Cl-), but not to R+:
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Donnan Equilibrium At equilibrium, the Nernst potentials for K+ and Cl- must be equal (E K = E Cl ) or: E k = kT q ln K + [ ] o K + [ ] i = E Cl = - kT q ln Cl - [ ] o Cl - [ ] i K + [ ] o K + [ ] i = Cl - [ ] i Cl - [ ] o
Background image of page 4
Example Problem A membrane is permeable to K+ and Cl-, but not to a large cation R+ (like in the figure above). Find the steady-state equilibrium concentration for the following initial conditions:
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/29/2010 for the course BME 314 taught by Professor Frey during the Fall '08 term at University of Texas at Austin.

Page1 / 12

BME 314 Lecture 14 2010 - BioelectricPhenomenaII Krish Roy,...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online