BME314HW1 - B ME 314 Homework 1 Paul Gonzales 14040 1. i....

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BME 314 Homework 1 Paul Gonzales 14040 1. i. Four properties that are important for the success of a bone substitute are its mechanical properties (whether allowed to withstand lots of weight), chemical properties (to ensure that the material is not degradable), biological properties (to ensure that the bone will interact with surrounding tissues and cells), porosity (to enable a network of red blood cells, etc.) highly crystalline, strong, smooth, non porous, hydrophilic 2. ii. E = young’s modulus E = (F/A) / (dL/L0) = (mg/A)/(.35L/L0) = (65*9.81/3.14*(.02^2))/ (.35*.06/.06) = 1.45 E6 N/m^2 iii. Su = Ultimate Strength Sy = Yield Strength Sf = Fracture Strength if material is more crystalline the plastic region is smaller than elastic region smaller elastic region with steep slope 3. a) Implanted scaffold with VEGF Major concerns: would require a continuous supply of the growth
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BME 314 Homework 1 Paul Gonzales 14040 factor, if the scaffold is not designed correctly (diffusion of growth factor could become a problem) Major Advantages: if encapsulated, would not provoke an immune response (closed system), induces angiogenesis (to create new blood vessels that would transport more nutrients) diffusion of VEGF out of pourous alter porosity concerned about immune response biocompatibility of material b) advanced free form fabrication technique Major concerns: biocompatibility of the material used (would have to attach to blood vessels), acute or chronic inflammation (due to invasiveness of body), requires an invasive approach (since scaffold and cells are being implanted into the body, could require more than one surgery), protein adsorption upon entering the body (attach upon entry); needs to be allogenic. Major Advantages: if it works it could become a permanent solution for
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This note was uploaded on 11/29/2010 for the course BME 314 taught by Professor Frey during the Fall '08 term at University of Texas at Austin.

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BME314HW1 - B ME 314 Homework 1 Paul Gonzales 14040 1. i....

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