LAB 2 PRELAB Worksheet - BIO152 Lab 2: Patterns of...

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BIO152 Lab 2: Patterns of Inheritance - PRELAB Worksheet Part I—Pedigree Construction (adapted from Barry Chess Natural Sciences Division, Pasadena City College, Pasadena, CA) Greg and Olga were both a little worried. Starting a family presented choices and responsibilities far more long-reaching and complex than anything either of them had encountered before, and sitting here in the reception area of the genetic counselor’s office they were beginning to feel the pressure. They had met four years earlier in the hemophilia clinic where Greg was waiting for his brother Jeff to get an injection of factor VIII, a protein that helps the blood to clot. When a person’s factor VIII level is very low (less than 1% of normal), even the smallest cuts can be troublesome and uncontrolled internal bleeding is common. Complications include swelling, joint damage, and an increased likelihood of neurological complications due to intracerebral bleeding. Even simple surgical procedures such as tooth extractions become far more risky. Jeff’s condition was noted by his pediatrician shortly after birth when his circumcision bled profusely. Since then, Jeff has received monthly injections of factor VIII, either at home or (twice a year) at a clinic where his physical condition is reviewed by a physician’s assistant. At first these injections contained clotting factor isolated from the blood of human donors but, for the last 10 years or so, he has received recombinant clotting factor, which is genetically engineered. It was in that clinic waiting room that Greg struck up a conversation with Olga, who was
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This note was uploaded on 11/30/2010 for the course BIO BIO152 taught by Professor Cordon during the Fall '09 term at University of Toronto- Toronto.

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LAB 2 PRELAB Worksheet - BIO152 Lab 2: Patterns of...

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