Experiment 6 - Vanessa Chew Ashleigh Ward Chem 3AL October...

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Vanessa Chew Ashleigh Ward Chem 3AL October 31, 2010 Experiment 6: Thin Layer Chromatography Discussion None of the solvents caused significant hydrolysis of acetylsalicylic acid. Hence, the two TLC solvents used in Part II were narrowed down primarily based on the amount of separation they yielded. Of the four solvents, the system of 10:10:1 toluene:EtOAc:AcOH gave the best separation of the four compounds run; the compounds were separated by approximately 0.10 or more in R f . 60:40 Hex:EtOAc failed to separate acetaminophen and caffeine, yielding an R f of 0.04 for both compounds. Finally, the two remaining solvents, 92:8 EtOAc:AcOH and 100% EtOAc, yielded similar separation results, but 92:8 EtOAc:AcOH was eventually rejected as it caused smearing of the caffeine spot. The analgesic, Unknown D, was identified through matching of its R f with that of other known compounds in the same solvent systems. In 100% EtOAc, the unknown had an R f of 0.65, which was closest to that of two other compounds, aspirin (0.60) and ibuprofen (0.70). But in 10:10:1
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This note was uploaded on 11/29/2010 for the course CHEM 3AL taught by Professor Li during the Fall '08 term at University of California, Berkeley.

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Experiment 6 - Vanessa Chew Ashleigh Ward Chem 3AL October...

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