Time+for+Your+Skin+Transfusion++-+ScienceNOW

Time for Your Skin T - AAAS.ORG FEEDBACK HELP LIBRARIANS Daily News Enter Search Term ALERTS ACCESS RIGHTS ADVANCED MY ACCOUNT SIGN IN News Home

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ENLARGE IMAGE New blood. Researchers made these red blood cells by partially reprogramming skin cells. Credit: Szabo et al., Nature, Advanced Online Publication (2010) You can't get blood from a stone, but you may be able to get it from skin. Researchers have coaxed adult skin cells to morph into a variety of blood cells. The scientists transformed the cells into blood without first "reprogramming" them into cells that resemble embryonic stem cells, suggesting that this transformation might not be necessary for making replacement tissues. Embryonic stem (ES) cells can potentially transform into any cell type in the body, but they carry a heavy load of ethical baggage. By inserting four genes or RNA sequences , researchers can reprogram adult cells, coercing them to "unspecialize" into induced pluripotent stem (iPS) cells with the talents of ES cells. Although scientists have spurred iPS and ES cells to develop into blood cells, both kinds of stem cells remain problematic. For one thing, researchers are worried about their potential to become cancerous. Another limitation, says stem cell biologist Mickie Bhatia of McMaster University in Hamilton, Canada, is that the resulting blood cells make little of the adult variety of hemoglobin, the body's oxygen-toting protein,
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This note was uploaded on 12/02/2010 for the course BIO SCI Bio Sci E1 taught by Professor Catherineloudin during the Spring '10 term at UC Irvine.

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Time for Your Skin T - AAAS.ORG FEEDBACK HELP LIBRARIANS Daily News Enter Search Term ALERTS ACCESS RIGHTS ADVANCED MY ACCOUNT SIGN IN News Home

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