Carbonyl Condensation Reactions

Carbonyl Condensation Reactions - Carbonyl Condensation...

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Carbonyl Condensation Reactions Chapter 23 Part 1 Condensation Reactions ± Carbonyl compounds are both the electrophile and nucleophile in carbonyl condensation reactions Condensation Reactions ± A combination of an α -substitution reaction and a nucleophilic addition reaction between 2 carbonyl compounds. ± These carbonyl compounds include: aldehydes, ketones, esters, amides, acid anhydrides, thiol esters and nitriles.
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23.1 Mechanism of Carbonyl Condensation Reactions (Base Catalyzed) ± Carbonyl condensation reactions utilize α -substitution steps ± An enolate ion adds as a nucleophile to the electrophilic acceptor 23.2 Condensations of Aldehydes and Ketones: The Aldol Reaction ± Acetaldehyde reacts in basic solution (NaOEt, NaOH) with another molecule of acetaldhyde ± The β -hydroxy aldehyde product is aldol ( ald ehyde + alcoh ol ) ± This is a general reaction of aldehydes and ketones Aldol Mechanism:
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Aldol Reactions ± The aldehyde or ketone must have an α - hydrogen ±
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This note was uploaded on 12/05/2010 for the course CHM 239 taught by Professor Arney during the Spring '10 term at Sam Houston State University.

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Carbonyl Condensation Reactions - Carbonyl Condensation...

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