Midterm_Answers - Chemistry of Drugs: Midterm Answers 1....

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Chemistry of Drugs: Midterm Answers 1. Aspirin works well to relieve arthritis, acetaminophen reduces fever 2. Cold viruses are easily transmitted by such simple acts as shaking hands 3. The drug ranitidine (Zantac) fits into histamine receptors in the stomach and blocks the acid-releasing effect of histamine 4. PCP and LSD users can have recurring hallucinations 5. LSD is not physically addictive and is not a naturally occurring compound although it can easily be prepared from an ergot extract 6. PPA (phenylpropanolamine), a decongestant that was found in cold tablets, was also used in diet pills 7. Aspirin (ASA) interferes with the production of prostaglandins responsible for the production of acid in the stomach 8. Some drugs are not developed because of the lack of enough patients to make it profitable; nearly half of the antibiotic production goes to animal feed 9. Nicotine is physically addictive 10. Women may be more likely to get smoking-induced cancer. In addition, nicotine use can lead to weight loss 11. Reye Syndrome is thought to be triggered by taking aspirin. This applies to young people only 12. Migraine headaches affect women more then men, in addition, there appears to be a significant hereditary factor in migraines 13. Drugs are always tested for safety on healthy individuals 14. The use of tobacco causes more problems for the heart than even for the lungs 15. Tobacco was first smoked as a medicinal drugs to treat a variety of diseases 16. There are a variety of factors leading to heart disease from smoking. These include hemoglobin being tied up by carbon monoxide, increased blood clotting, damage to inner wall linings and a release of adrenalin leading to increased blood pressure 17. Duodenal ulcers are more prevalent then gastric ulcers; there is some evidence that Tagemet blocks androgen receptor sites 18. Penicillinase deactivates penicillin by breaking open the key ring structure of penicillin’s 19. The mode of action of penicillins are associated with the interference of cell wall construction of bacteria; sulfa drugs interfere with folic acid incorporation by bacteria and tetracyclines inhibit protein synthesis by bacteria 20. Cocaine is believed to produce its euphoric effect by blocking the re-uptake of dopamine by nerve cells 21. The coronary arteries stem from the aorta and encircle the heart 22. A heart attack is usually caused by the formation of a blood clot in the coronary arteries 23. Platelets inhibit blood clotting 24. In coronary bypass surgery the flow of blood is re-routed around a blocked coronary artery by using a vein taken from the leg 25. In balloon angioplasty, a blocked artery is opened by inflating a balloon at the end of a catheter inserted from the groin 26. The active ingredient in marijuana relives nausea associated with chemotherapy
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27. Cocaine is used in medicine as a local anesthetic 28. Withdrawal symptoms and tolerance are associated with addiction 29. Heroin is a synthetic derivative of morphine
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This note was uploaded on 12/02/2010 for the course EPSC EPSC 201 taught by Professor Alfredo during the Spring '09 term at McGill.

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Midterm_Answers - Chemistry of Drugs: Midterm Answers 1....

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