P2S10ANS_POST - 1. The image below is an electron...

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1. The image below is an electron micrograph of eukaryotic chromatin. a. (2 points) Name the globular structures visible in the micrograph. nucleosome b. (3 points) Draw and label a cartoon showing the arrangement of molecules within these globular structures. See Figure 24-26, a on p. 963 c. (4 points) List 2 higher order levels of organization in eukaryotic DNA. (Fig. 24-33, p. 968) Only two required 30 nm fiber (or solenoid) loops attached to the nuclear scaffold rosettes coils Chromatids d. (2 points) Name two types of modifications involved in chromatin remodeling. (Nelson and Cox, pp. 1136-8) Only two required changes in histone composition, changes in histone methylation, changes in histone acetylation, repositioning of nucleosomes, changes in DNA methylation, phosphorylation, sumoylation, and ubiquitination. (2 points) What is the function of chromatin remodeling? (Nelson and Cox, pp. 1136-8) Transcriptional regulation, i.e. relaxation of chromatin structure in order to permit transcription and condensation of chromatin to inactivate transcription.
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BIOBM 3300 2nd Prelim page 2 ANSWERS 2. a. (2 points) Give the specific name of the enzyme from E. coli shown associated with helicase in the Figure below. b. (2 points) Name the subunit labeled with a “B”. (Nelson & Cox, pp. 980-984) β -clamp (or β -subunit) (2 points) Name the property of the enzyme that results from the function of this subunit. (Nelson & Cox, pp. 980-984) processivity
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page 3 ANSWERS 3. a. (2 points) What is being synthesized in the Figure below? (Nelson & Cox, pp. 1053-6) Telomeres b. (2 points) Name the enzyme designated by the letter “A” in the Figure. (Nelson & Cox, pp. 1053-6) Telomerase (2 points) Of what type of enzyme is this an example? (Nelson & Cox, pp. 1053-6) Reverse transcriptase c. (2 points) What type of molecule is designated by the letter “B” in the Figure? (Nelson & Cox, pp. 1053-6) RNA d. (2 points) Discuss why this process is important. (Nelson & Cox, pp. 1053-4) As the 3' end of a linear chromosome is being replicated, when the 5' primer is removed via the 5' to 3' exonuclease activity of DNA pol I there is no 3' end onto which the replacement deoxynucleotides can be added. As a result, chromosomes shorten in this region each time they are replicated. The addition of non-coding telomeric repeat DNA to the ends of
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This note was uploaded on 11/29/2010 for the course MATH 1920 taught by Professor Pantano during the Spring '06 term at Cornell University (Engineering School).

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P2S10ANS_POST - 1. The image below is an electron...

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