Prelim 2 - Spring 2008 - BioBM 330 2nd Prelim Name _ 1...

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BioBM 330 Name ____________________________ 2nd Prelim 1 April, 2008 Please do not lift this sheet until the signal is given! Please be certain that your exam contains a total of 11 pages! Please write your name on EACH page. We urge you not to get bogged down on any one question. If you do not see the point fairly quickly, go on to the other questions and come back if time permits. You may have two hours for the whole exam. 1. _________ (8) 9. _________ (6) 2. _________ (6) 10._________ (11) 3. _________ (3) 11. _________ (3) 4. _________ (6) 12. _________ (2) 5. _________ (2) 13. _________ (3) 6. _________ (2) 14. _________ (8) 7. _________ (5) 15. _________ (4) 8. _________ (3) 16. _________ (15) Total _________________ (87) First Position (5' end) Second Position Third Position (3' end) U C A G Phe U U C C A A G G U C A G U C A G U C A G Phe Leu Leu Leu Leu Leu Leu Ile Met Ile Ile Val Val Val Val Ser Ser Ser Ser Pro Pro Pro Pro Thr Thr Thr Thr Ala Ala Ala Ala Tyr Stop Tyr Stop His Gln Gln His Asn Lys Asn Lys Asp Glu Asp Glu Cys Stop Trp Cys Arg Arg Arg Arg Ser Ser Arg Arg Gly Gly Gly Gly
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BioBM330 2nd prelim 4/1/08 Name: ___________________________2 1. a. (3 points) DNA pol I from E. coli has three domains each with a specific enzymatic activity. Name each of the enzymatic activities and briefly describe the function of each of these activities in DNA replication. b. (1 point) Specifically, why would DNA replication come to a halt in the absence of topoisomerase II? c. (4 points) In addition to DNA pol I and topoisomerase II described above, name four other enzymes involved in DNA replication and describe the function of each. (No more than one sentence for each, please.) 1) 2) 3) 4)
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Name: ___________________________3 2. a. (1 point) What are telomeres? b. (1 point) Are telomeres found in eukaryotic or prokaryotic DNA? c. (2 points) How are telomeres synthesized? d. (2 points) Why are telomeres important? 3. a. (2 points) What unique aspect of the amino acid sequence of histone proteins is crucial to their function? Explain. b.
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Prelim 2 - Spring 2008 - BioBM 330 2nd Prelim Name _ 1...

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