ProteinStructure

ProteinStructure - Welcome to MCB124 Fall 2010 Part 2...

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Unformatted text preview: Welcome to MCB124 Fall 2010 Part 2 Course info and resources Purpose Scope Grading Course info and resources Contacts: Enoch Baldwin Office hours: Tues 12-1 PM/Thurs 1-2 PM 4B Briggs Hall epbaldwin@ucdavis.edu Teaching Assistants: Roger Jesinghaus Office hours: Monday 9-11 AM 2064 SLB rpjesinghaus@ucdavis.edu Vu Trinh Office hours: Monday/Wednesday 1-2 PM 2061 SLB vbtrinh@ucdavis.edu Purpose Scope Welcome to MCB124 Fall 2010 Course info and resources Website: http://www-crystal. ucdavis.edu/course/mcb124/F10 Purpose Scope Grading Welcome to MCB124 Fall 2010 Course info and resources Website: http://www-crystal. ucdavis.edu/course/mcb124/F10 You MUST download articles via the UC Davis Net!! index >> lecture schedule >> readings resources list >> websites homework and answers grades Purpose Scope Grading Welcome to MCB124 Fall 2010 Course info and resources Purpose To develop an in-depth understanding of how polypeptide and nucleic acid structure, physical properties, and biochemistry direct function, while covering some of the experimental approaches to investigating these problems. Scope Grading Welcome to MCB124 Fall 2010 Course info and resources Purpose To develop an in-depth understanding of how polypeptide structure, physical properties, and biochemistry direct protein function, while covering some of the experimental approaches to investigating these problems. Applications: Academic: How life works Pharmaceutical: Drug and protein design Genomics: protein structure/function predictions Scope Grading Welcome to MCB124 Fall 2010 Course info and resources Purpose Scope Fundamentals of Protein and Nucleic Acid Structure Protein and Nucleic Acid Folding Forces that determine structure Thermodynamics How sequence determines structure* Bending, looping and supercoiling Protein-DNA Interactions Physical Principles Methodologies Basis for binding specificity Welcome to MCB124 Fall 2010 Course info and resources Purpose Scope Grading (part 2) 200 pts total Three quizzes (75 pts): Final (125 pts): covers all material for the second half Welcome to MCB124 Fall 2010 Molecular Biology DNA => ! RNA => protein Molecular Biology DNA => ! RNA => protein Modern Biology sequence => ! structure => function Lecture 1. Protein Structure IS SOMETHING HAPPENING? HOW DO WE KNOW? CAN WE PREDICT WHETHER IT WILL HAPPEN? Equilibrium Constants and Rates k for [B] eq A <---> B K = _____ k rev [A] eq WE NEED TO MAKE MEASUREMENTS! Equilibrium Constants and Free Energies k for K = [B] eq A <---> B ____ k rev [A] eq G = G B- G A = -RTlnK Equilibrium Constants and Free Energies k for K = [B] eq A <---> B ____ k rev [A] eq G = G B- G A = -RTlnK Rememeber, for G you need to COMPARE the free energies of beginning AND ending states => MUST KNOW ABOUT BOTH What do free energies have to do with molecules?...
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ProteinStructure - Welcome to MCB124 Fall 2010 Part 2...

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