ProteinStructure - Welcome to MCB124 Fall 2010 P a rt 2...

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Welcome to MCB124 Fall 2010 Part 2 • Course info and resources • Purpose • Scope • Grading
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• Course info and resources Contacts: Enoch Baldwin Office hours: Tues 12-1 PM/Thurs 1-2 PM 4B Briggs Hall [email protected] Teaching Assistants: Roger Jesinghaus Office hours: Monday 9-11 AM 2064 SLB [email protected] Vu Trinh Office hours: Monday/Wednesday 1-2 PM 2061 SLB [email protected] • Purpose • Scope Welcome to MCB124 Fall 2010
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• Course info and resources Website: http://www-crystal.ucdavis.edu/course/mcb124/F10 • Purpose • Scope • Grading Welcome to MCB124 Fall 2010
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• Course info and resources Website: http://www-crystal.ucdavis.edu/course/mcb124/F10 You MUST download articles via the UC Davis Net!! index >> lecture schedule >> readings resources list >> websites homework and answers grades • Purpose • Scope • Grading Welcome to MCB124 Fall 2010
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• Course info and resources • Purpose To develop an in-depth understanding of how polypeptide and nucleic acid structure, physical properties, and biochemistry direct function, while covering some of the experimental approaches to investigating these problems. • Scope • Grading Welcome to MCB124 Fall 2010
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• Course info and resources • Purpose To develop an in-depth understanding of how polypeptide structure, physical properties, and biochemistry direct protein function, while covering some of the experimental approaches to investigating these problems. Applications: • Academic: How life works • Pharmaceutical: Drug and protein design • Genomics: protein structure/function predictions • Scope • Grading Welcome to MCB124 Fall 2010
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• Course info and resources • Purpose Scope Fundamentals of Protein and Nucleic Acid Structure Protein and Nucleic Acid Folding Forces that determine structure Thermodynamics How sequence determines structure* Bending, looping and supercoiling Protein-DNA Interactions Physical Principles Methodologies Basis for binding specificity Welcome to MCB124 Fall 2010
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• Course info and resources • Purpose • Scope • Grading (part 2) 200 pts total Three quizzes (75 pts): Final (125 pts): covers all material for the second half Welcome to MCB124 Fall 2010
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Molecular Biology DNA => RNA => protein
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Molecular Biology DNA => RNA => protein Modern Biology sequence => structure => function
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Lecture 1. Protein Structure
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IS SOMETHING HAPPENING? HOW DO WE KNOW? CAN WE PREDICT WHETHER IT WILL HAPPEN?
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Equilibrium Constants and Rates k for [B] eq A <---> B K = _____ k rev [A] eq WE NEED TO MAKE MEASUREMENTS!
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Equilibrium Constants and Free Energies k for K = [B] eq A <---> B ____ k rev [A] eq Δ = G B - G A = -RTlnK
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Equilibrium Constants and Free Energies k for K = [B] eq A <---> B ____ k rev [A] eq Δ = G B - G A = -RTlnK Rememeber, for G you need to COMPARE the free energies of beginning AND ending states => MUST KNOW ABOUT BOTH
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What do free energies have to do with molecules?
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