BIO311C_F10_Chapter_17_part_3

BIO311C_F10_Chapter_17_part_3 - Mutations Chapters 17 and...

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Mutations Chapters 17 and part of 16 344-346, 316-318
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Fig. 17-22 Wild-type hemoglobin DNA mRNA Mutant hemoglobin DNA mRNA 3 3 3 3 3 3 5 5 5 5 5 5 C C T T T T G G A A A A A A A G G U Normal hemoglobin Sickle-cell hemoglobin Glu Val
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Lysis of RBC Low RBC counts Clog BV
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Cause of mutations Spontaneous mutations Can occur during DNA replication, repair etc Mutagens Are physical or chemical agents that can cause mutations
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Point mutations Are changes in just one base pair of a gene Can affect protein structure/function
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Types of Point Mutations Point mutations within a gene can be divided into two general categories Base-pair substitutions Base-pair insertions or deletions
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Base pair substitutions Is the replacement of one nucleotide and its partner with another pair of nucleotides Silent Missense Nonsense
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1) Silent mutations have no effect on the amino acid produced by a codon because of redundancy in the genetic code
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Fig. 17-23a
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