BIO311C_F10_Chapter_17_part1

BIO311C_F10_Chapter_17_part1 - Gene expression Process by...

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Gene expression Process by which DNA directs synthesis of proteins (or just RNA) Involves: Transcription Translation
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Central dogma of modern biology
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Transcription and RNA processing Pages 331-336
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Transcription DNA directed synthesis of RNA Comparing DNA and RNA
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What we will cover Where does transcription occur in a eukaryotic as against a prokaryotic cell? Process of transcription Pre-mRNA processing in eukaryotes Exons vs. introns
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Fig. 17-3b-3 TRANSCRIPTION Nuclear envelope DNA Pre-mRNA RNA PROCESSING mRNA TRANSLATION Ribosome Polypeptide
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Eukaryotes Transcription and Translation occur in separate compartments RNA polymerase II – forms pre mRNA (primary transcript) Processed (modified) to mRNA
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Prokaryotes Prokaryotic cell. In a cell lacking a nucleus, mRNA produced by transcription is immediately translated without additional processing. (a) TRANSLATION TRANSCRIPTION DNA mRNA Ribosome Polypeptide
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Prokaryotes Transcription and translation are coupled RNA made on transcription is mRNA RNA polymerase (RNAP) - transcription
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Some nomenclatures Promoters: DNA sequences near the beginning of genes that signal RNA polymerase where to begin transcription RNA polymerase binds the promoter Terminators: Sequences in the RNA product that tells RNA polymerase where to stop (encoded by the DNA) Transcription unit: stretch of DNA transcribed into RNA
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Some more nomenclature convention (coding strand) (sense strand) (non-coding strand) (anti-sense strand) RNAP
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