10-20 - Review session for Exam 2 (through Ch 7): Friday...

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1 Which molecule reacts faster by S N 2? Review session for Exam 2 (through Ch 7): Friday from 4:30-6:00 in Javits 100 77 AB Steric hindrance in transition state Nu: Why does A react faster than B by S N 2? Steric hindrance in transition state Nu Nu     78 E R B A B A 2. basicity of the leaving group. 1. nucleophilicity 3 structure of the S N 2 79 G E R 3. structure of the substrate. 4. reaction medium (solvent). 5. temperature Substitution Reaction Mechanisms S N 2 C Nu X + CX Nu 80 An alternative reaction mechanism: C Nu fast S N 1 S N 1 = S ubstitution N ucleophilic 1 st Order rate = k G C X δ δ C X 81 E R C Nu: S N 1 rate = k G C X δ δ C C Nu: δ δ If we use a more nucleophilic nucleophile, the rate will: i 82 E R a. increase b. decrease c. not change
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2 Factors affecting S N 1 reaction rate G C C X 1. Nucleophilicity (basicity) of the nucleophile.
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This note was uploaded on 12/05/2010 for the course CHE 321 taught by Professor Fowler/sampson during the Fall '08 term at SUNY Stony Brook.

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10-20 - Review session for Exam 2 (through Ch 7): Friday...

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