11-15 - In a 10g sample of rapamycin approximately how many...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 11/16/2010 In a 10g sample of rapamycin approximately how many grams would have a 13C at the indicated methyl group? HO HO O What would the size of 13C 1H coupling constants compared to the 1H 1H coupling constants be for the following methyl group ? A. Larger HO HO B. Smaller O Natural Natural abundance of N O OH OH O O O O O OH O 13C 12C = 1% N O O O O OH O Most carbon, 99%, is O O A. 0.01 g C. 1.0 g B. 0.1 g D. 5 g OH OH O O O O Most Most 13C spectra are recorded using proton decoupling so that carbon atoms appear as single lines. rapamycin C51H79NO13 rapamycin C51H79NO13 What are the maximum number of adsorptions that could be observed for the 13C spectrum of rapamycin? A. 1 HO HO B. 25 O C. 51 D. 102 E. >500 O O OH N O OH OH O O O O O Give the structure of C5H10O. Each Each chemically different carbon atom in a structure results in one absorption The The position of a carbon atom absorption depends upon its chemical environment O H O pure chemical compound C5H10O O O A B O C D E O C51H79NO13 What is the product of the following reaction? A. B. 2° What is the product of the following reaction? A. B. 2° 1° 13C spectrum of product. 1 11/16/2010 What is the mechanism of the following reaction? initiation propagation termination 8 The chlorination of methane. When a bond is broken two radicals are produced. A H H C H H H C H Cl H C H H C H B H Which C-H bond of propane, A or B, is stronger? 9 10 Which radical is more stable? Which radical is more stable? H H C H H C H C H H H H C H H C H H C H H C H H H H H H C H H C H H C C 1° H + H H H H C H H C H H C H H C H H H C H C H H H H H H C H H C H H C H H C C H C H H 1° H + H H H C H H A H C C H H A H C C H H 2° H C H H+ H 2° H C H H+ H B H B H H H H C H C H H C H 12 H 11 2 11/16/2010 Which Which reaction has the larger BDE (∆H˚)? Using Using bond dissociation energies (BDE) estimate the ∆H° of the following reaction. + + H H C H H C H H C H H C H H H H H H C H H C H H C H H C H C H C A. 1° H + H H BDE (∆H˚) 423 kJ/mol H C H H B. B. 2° H C H H+ H 413 kJ/mol bonds of reactants (440 + 243) 683 - bonds of products (352 + 432) 784 C. -101 = heat of reaction = -101 kJ/mol E. +32 14 F. 0 13 A. -784 B. +682 D. +439 What is the ∆H° of the first step in the accepted mechanism of the chlorination of methane? 440 kJ/mol + The chlorination of methane involves two steps? 440 kJ/mol + H C HH + 432 kJ/mol H C HH + 432 kJ/mol ∆H° = +8 H C HH + + H 243 kJ/mol 352 kJ/mol C HH + + 243 kJ/mol 352 kJ/mol What is the ∆H° of the second step in the accepted mechanism of the chlorination of methane? A. -440 B. +109 C. -8 D. +8 E. -109 15 F. +440 A. -440 B. +109 C. -8 D. +8 E. -109 16 F. +440 What is the overall ∆H° for the chlorination of methane? H + C HH + ∆H° = +8 H C HH + + ∆H° = -109 ∆H° = -101 17 3 ...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern