2010-10-01_ Matthews_2 - Antimicrobials II AcidSynthesis...

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Anti microbials II Inhibitors of Protein and Nucleic Acid Synthesis Jason Matthews [email protected]
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Protein synthesis 3 phases Initiation Elongation Termination Final step disassembly
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Ribosomal Complex Receive and translate genetic instructions to form specific proteins 2 subunits 30S and 50S Combine to form complete 70S ribosome fast ~20 amino acids/sec pro vs 2 a.a./sec euk Antimicrobials don’t bind to mammalian ribosomes Mammalian ribosomes 80S Exceptions – tetracyclines, chloramphenicol
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Alberts et al. Molecular Biology of the Cell 4 th edition Bacterial Eukaryotes
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