2010-10-06 Matthews_4 - Antivirals HIV Jason Matthews...

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Jason Matthews [email protected] Antivirals HIV
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HIV Human immunodeficiency virus ssRNA virus ~ 100 nm in diameter Dense cylindrical nucleoid with: Core proteins Genomic RNA Reverse transcriptase Envelope Lipid membrane derived from host cell outer membrane Covered by glycoproteins GP120 and GP41
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accessed 09/05 Lifecycle of a Retrovirus HIV binds to cell - CD4-receptor binding site on host T- lymphocytes or macrophages Fuses with cell and injects core, uncoating Reverse transcriptase makes single-strand DNA copy of viral RNA
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