2010-10-08 Matthews_5[1] - Anti-parasitic Agents...

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Anti-parasitic Agents
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Antiparasitic Agents leading cause of chronic illness directly or indirectly in the developing world platyhelminthes tapeworms Helminths worms nematodes – reside in GI roundworms, pinworms Protozoan – single celled malaria trypanosomiasis toxoplasmosis
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Ascaris lumbricoides Roundworm (1) eggs passed in stools (2) Grow in soil (3) Infectious if fertilized (4) penetrate to alveoli, ascend and swallowed (5) Larvae infest small intestine grow to adults attach to intestinal wall – blood loss (6) Adults worms eliminated 1 2 years Life Cycle 1.4 billion infected world wide significant morbidity poor hygiene – mild symptoms migrate and exit body females: 20 to 40 cm adult male: 15 to 30 cm
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Tenia solium or T. saginata 1/1000 NA about 10% developing Tapeworms platyhelminths ingested with poorly cooked infected meat (4 6 meters) mild infections asymptomatic severe GI abnormalities – discomfort, D/V eggs can also infect humans and cause cysticercosis (larval cysts in lung, liver, eye and brain) resulting in blindness and neurological disorders.
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T. saginata Adults can live in sm intestine for 25 years
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Albendazole and Mebendazole prevents microtubule polymerization by binding to β tubulin in parasite, irreversibly depleting glycogen stores po, well tolerated, extensive 1 st pass met intestinal nematodes Pyrantel pamoate muscular depolarization, release of agonist at
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