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Unformatted text preview: Small Group Session: Anti‐Infectious Disease Agents. Oct 13, 2010 Case study: CW is a 21 year old male who presents to the ED with a 3 day history of worsening pain, redness and swelling on his right leg, after he fell off his mountain bike. Upon PE his temperature is 39.2oC, BP 112/69 mmHg; HR is 80bpm and RR is 24 breaths/min. He has NKDA. His leg has a visible abrasion, is swollen, warm and extremely tender. 1. What is CW most likely suffering from (i.e. diagnosis) ‐ and what pathogens are often associated with this diagnosis? What class of drug is likely ideal for treatment and why? No cultures are done and initial IV drug therapy is prescribed. 2. What would be your recommendation as the initial drug therapy prescribed to CW? Explain your choice, its MOA and any concerns that might accompany its use? Eventually CW is given oral medication and released from the hospital however within a few days he returns to the ED complaining of a fever and chills as well as vomiting and diarrhea. There is intense pain at the original site of injury with skin discoloration and blisters. 3. What do you believe has happened to CW (i.e. what is the diagnosis/cause) and what is your recommendation for therapy? Briefly explain your reasoning. An Open‐Label, Randomised Study of Dihydroartemisinin‐Piperaquine versus Artesunate‐ Mefloquine for Falciparum Malaria in Asia. (2010). Plos ONE: 5(7):e11880 1. Briefly describe the MOA for the drugs that are being compared in this study and explain their advantage over chloroquine and primaquine‐phosphate? 2. Explain the difference between the PCR‐corrected cure rates and the uncorrected cure rates? Why do you think the authors chose to include both of these measurements? 3. Briefly explain the life‐cycle of a malarial (P. falciparum) infection and associated pathology. Why did the authors examine both the ITT and per protocol population? Group discussion: Do you agree with this paper that ADHA/PQP should be used a first line treatment for falciparum malaria? ...
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This note was uploaded on 12/03/2010 for the course PHAMACOLOG pcl470 taught by Professor Arnot during the Fall '10 term at University of Toronto- Toronto.
- Fall '10