Behavioral Pharmacology 2010Bb - BEHAVIORAL PHARMACOLOGY Dr...

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BEHAVIORAL PHARMACOLOGY Dr. Larry Grupp Department of Pharmacology University of Toronto
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LEARNING POINTS 1. Stimulus properties of drugs 2. Rewarding properties of drugs 3. Drug tolerance 4. Animal models of anxiety,depression 5. Animal tests for memory, pain, drug abuse
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BEHAVIORAL PHARMACOLOGY The study of the relationship between the physiological actions of drugs and their effects on behavior and psychological function = +
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Set and setting The behavioral effects of drugs are due to complex interactions among pharmacological actions of drugs, the state of the organism (“set”), Rate dependency (e.g. Ritalin for ADHD) and the environmental circumstances surrounding drug administration (“setting”)
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BEHAVIORAL PHARMACOLOGY Pharmacology at the service of behavior Use of drugs to study mechanisms of behavior e.g. want to see whether sexual behavior is influenced by anxiety Example question : Does anxiety interfere with sexual behavior Answer: Make male fearful using a benzodiazepine inverse agonist (i.e change the “set”) and observe his attention to receptive female
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BEHAVIORAL PHARMACOLOGY Behavior at the service of pharmacology Use of behavioral techniques to establish the effect of drugs e.g. drug development for anxiety, depression etc. Example question : Is Drug X an anxiolytic ? Answer: Put animals in a fearful situation and see whether Drug X breaks the freezing response
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(I) Stimulus Properties of Drugs Drug discrimination procedure: Method to ask animals about the interoceptive
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