Gingko Biloba for preventing Cog. Decline JAMA 2009

Gingko Biloba for preventing Cog. Decline JAMA 2009 -...

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current as of September 21, 2010. Online article and related content http://jama.ama-assn.org/cgi/content/full/302/24/2663 . 2009;302(24):2663-2670 (doi:10.1001/jama.2009.1913) JAMA Beth E. Snitz; Ellen S. O’Meara; Michelle C. Carlson; et al. Adults: A Randomized Trial for Preventing Cognitive Decline in Older Ginkgo biloba Supplementary material http://jama.ama-assn.org/cgi/content/full/302/24/2663/DC1 eTable and eFigures Correction Contact me if this article is corrected. Citations Contact me when this article is cited. This article has been cited 2 times. Topic collections Contact me when new articles are published in these topic areas. Drug Therapy, Other Psychiatry; Psychopharmacology; Randomized Controlled Trial; Drug Therapy; Disorders; Dementias; Neurogenetics; Complementary and Alternative Medicine; Aging/ Geriatrics; Neurology; Alzheimer Disease; Behavioral Neurology; Cognitive Related Letters . 2010;303(15):1477. JAMA Beth E. Snitz et al. In Reply: . 2010;303(15):1477. JAMA Lei Feng. and Cognitive Decline Ginkgo biloba http://pubs.ama-assn.org/misc/permissions.dtl [email protected] Permissions http://jama.com/subscribe Subscribe [email protected] Reprints/E-prints http://jamaarchives.com/alerts Email Alerts at University of Toronto on September 21, 2010 www.jama.com Downloaded from
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ORIGINAL CONTRIBUTION Ginkgo biloba for Preventing Cognitive Decline in Older Adults A Randomized Trial Beth E. Snitz, PhD Ellen S. O’Meara, PhD Michelle C. Carlson, PhD Alice M. Arnold, PhD Diane G. Ives, MPH Stephen R. Rapp, PhD Judith Saxton, PhD Oscar L. Lopez, MD Leslie O. Dunn, MPH Kaycee M. Sink, MD Steven T. DeKosky, MD for the Ginkgo Evaluation of Memory (GEM) Study Investigators G INKGO BILOBA IS MARKETED widely and used with the hope of improving, prevent- ing,ordelayingcognitiveim- pairmentassociatedwithagingandneu- rodegenerative disorders such as Alzheimer disease. The primary out- come analysis from the Ginkgo Evalu- ation of Memory (GEM) study, the largest completed randomized, double- blind, placebo-controlled dementia prevention trial to date, 1 found that G biloba , 120 mg twice daily, was not ef- fective in reducing the incidence of Alz- heimer dementia or dementia overall. Beyond consideration of a clinical de- mentia outcome, however, it is pos- sible that G biloba may have had more subtle, therapeutic effects on the rate of cognitive change. Specifically, G bi- loba mayhavepreventedordelayedage- related changes in individuals with nor- Author Affiliations: Departments of Neurology (Drs Snitz, Saxton, Lopez, and DeKosky and Ms Dunn) and Epidemiology (Ms Ives), University of Pittsburgh, Pitts- burgh, Pennsylvania; Department of Biostatistics, Uni- versity of Washington, Seattle (Drs O’Meara and Ar- nold); Department of Mental Health, Johns Hopkins Medical Institutions, Baltimore, Maryland (Dr Carl- son); Departments of Psychiatry and Behavioral Medi- cine (Dr Rapp) and Internal Medicine (Geriatrics/ Gerontology), School of Medicine (Dr Sink), Wake For- est University, Winston-Salem, North Carolina; and School of Medicine, University of Virginia, Charlottes- ville (Dr DeKosky).
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