Muslce Relaxants_10Bb - Muscle Relaxants The Neuromuscular...

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Muscle Relaxants The Neuromuscular Junction
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Lecture Overview I. Review somatic nervous system II. Physiology of the neuromuscular junction The role of Ach and nACh R III. Neuromuscular Blocking Agents 1. Toxins 2. Non-depolarizing Blockers 3. Depolarizing Blockers 4. Others IV. Therapeutics Clinical use of muscle relaxation Myasthenia Gravis and Lambert Eaton
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I. SOMATIC vs. AUTONOMIC Structures innervated Mode of action Effect of de-nervation SOMATIC NERVOUS SYSTEM CNS PNS SKELETAL MUSCLE MYELINATED CHOLINERGIC ACh NICOTINIC RECPTOR
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Somatic Neuron Pathway Fig. 12.13 Germann and Stanfield
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Figure 12.15 Communication at the Neuromuscular Junction (Sarcolemma)
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