Unformatted text preview: Systems Pharmacology PCL 470Y 2010‐2011 Location: FG 103 M:3‐4 pm W:9‐10 am F: 9‐10 am Small Group Sessions: MANDATORY and during lecture hours (see below). Location of these sessions will be outlined on Blackboard prior to each session, with posted questions, articles & case studies. Required Textbook: Principles of Medical Pharmacology. 7th Ed. Kalant, Grant & Mitchell Course Coordinator Dr. Michelle Arnot 4219 Medical Sciences Building Department of Pharmacology [email protected] 416‐978‐3164 Office Hours: generally Tuesday 1‐2 and Thursday 11‐12. OR make an appointment or find me before/after class Graduate Teaching Assistants: Carolyn Ptak –[email protected] Andrew Liuni – [email protected] Alex Wu‐ [email protected] Vaneeta Verma‐ [email protected] Meghan Larin – [email protected] Laura MacPherson‐ [email protected] Matthew Binnington‐ [email protected] Course Breakdown Midterm I Midterm II Midterm III Online quizzes (best 8 of 12) Small group session points Drug Review Final Total Due Date Nov . 10 Jan. 24 Mar. 16 Dec . 8 TBD 14% 14% 14% 8% 10% 10% 30% 100% Date Sept 13 Sept 15 Sept 17 Lecture Number 1 2 Topic Intro: REVIEW PK and PD review Introduction to the Small Groups (in lecture) Paper Discussion Vitamins and Erythropoiesis Vitamins and Bone Metabolism Vitamins, Herb and Supplements Herbs and Nutritional supplements Paper discussion Anti‐Infectious Agents I Anti‐Infectious Agents II Anti‐Infectious Agents III Anti‐Infectious Agents IV Anti‐Infectious Agents V Thanksgiving Case Study/Small Group I Intro: CNS and PNS Autonomic Nervous System I Autonomic Nervous System II Autonomic Nervous System III Autonomic Nervous System IV Muscle Relaxants I Lecturer Arnot Arnot Arnot Chapter Number 1‐8 1‐8 Ethics and Drug‐ Review Writing Assignment 63, 39 63, 65 63‐65 64 Sept 20 Sept 22 Sept 24 Sept 27 3 4 5 6 Arnot Arnot Arnot Arnot QUIZ #1 Sept 29 Oct 1 Oct 4 Oct 6 7 8 9 10 Matthews Matthews Matthews Matthews 49‐53, 55 49‐53, 55 49‐53, 55 49‐53, 55 Oct 8 Oct 11 QUIZ #2 Oct 13 Oct 15 Oct 18 Oct 20 Oct 22 Oct 25 QUIZ #3 Oct 27 11 12 13 14 15 16 17 Matthews Arnot Arnot Arnot Arnot Arnot Arnot 49‐53, 55 11 11 12‐14 12‐14 12‐14 15 Oct 29 Nov 1 Nov 3 QUIZ#4 Nov 5 18 19 20 Nov 8‐9 Nov 10 Nov 12 Nov 15 Nov 17 Nov 19 Nov 22 QUIZ#5 Nov 24 Fall Break 21 22 23 24 25 26 Nov 26 27 Nov 29 Dec 1 Dec 3 28 29 30 Dec 6 Dec 8 QUIZ#6 Jan 10 Jan 12 31 32 33 Jan 14 Jan 17 34 35 Muscle Relaxants II Pharmaco‐therapy of Acid‐ Peptic Disorders Case Study/Small Group II Overview of CNS‐ anatomy and neurotransmitters Term Test 1 Lectures 1‐18 Anti‐Convulsant Drugs Anxiolytics and Hypnotics Anti‐depressants and Mood Stabilizers Anti‐Migraine Agents Cognitive Enhancers Neurodegeneration: Agents Modifying Movement Control (PD and HD Neurodegeneration: Agents Modifying Movement Control (PD and HD) Alcohol Opioids Analgesics and Antagonists Behavioral Pharmacology‐ Addiction Anti‐Psychotic Agents Case Study/Small Group III WINTER BREAK Adrenal Steroid Thyroid Hormones and Antihyperthyroid Agents Gonadotrophics and Gonadal Hormones I Gonadal Hormones Arnot Arnot Burnham 15, 41, 42 41, 42 16 Burnham Arnot Arnot Arnot Mittmann Salahpour 18 Salahpour Grupp Grupp Grupp 22 19 69,70 Grupp Schimmer Schimmer 24 48 45 Schimmer Schimmer 46 46 Jan 19 Jan 21 QUIZ# 7 Jan 24 Jan 26 36 37 Jan 28 Jan 31 38 39 Feb 2 Feb 4 Feb 7 QUIZ #8 Feb 9 Feb 11 Feb 14 Feb 16 Feb 18 Feb.RDG WK Feb 28 QUIZ #9 Mar 2 Mar 4 Mar 7 Mar 9 Mar 11 Mar 14 QUIZ#10 Mar 16 40 41 42 43 44 45 46 47 48 49 50 51 52 and Oral Contraceptives Anti‐diabetic Drugs: Recent Developments Case Study/Small Group IV Term Test II (lecture 19‐35) Prostaglandins and Anti‐Inflammatory Agents Anti‐Inflammatory Agents Histamine and Anti‐ Histamine Paper Discussion Respiration: Asthma, COPD & cough reflex Respiration: Asthma, COPD & cough reflex Case Study/Small Group V CV overview Digitalis Glycosides & Positive Inotropics Anti‐arrhythmic Vasodilators Renal Diuretics Treatment of Hypertension Hyperlipoproteinemias (Cholesterol) Drugs Affecting Hemostasis I Hemostasis II Anaesthetics I AnaestheticsII Case Study Small Group VI Term Test III (Lectures 37‐52) Schimmer Ramsey 47 27 Ramsey Arnot 28 30 Arnot Arnot Arnot Arnot Dorian Al‐Hesayen Arnot Arnot Arnot Arnot Belo Belo Belo 36 36 31 32 33 34 37 37 35 38 20 21 Mar 18 Mar 21 Mar 23 Quiz #11 Mar 25 Mar 28 Mar 30 Apr 1 Apr 4 QUIZ #12 Apr 6 TBD 53 54 55 56 57 58 59 FINAL Overview of Immune System Pharmacology of Immune System Pharmacology of Immune System Overview of Cancer Anti‐neoplastic Drugs I Anti‐neoplastic Drugs II Gene Therapy Case Study/Small Group VII REVIEW Lectures 53‐59 Cumulative Semple Semple Semple McPherson McPherson McPherson Grant Arnot 40 40 40 57 57 57 Small group sessions will discuss clinical case studies and recently published articles on a specific “unit/system”. Small group questions will be posted to the class on Bb and answers will be presented individually and discussed during small group sessions; points will be based on attendance/ participation during these sessions as well as individual responses to questions (preparation, succinct communication/explanation). Teaching Assistants will also spend time reviewing some of the more difficult section material and answering questions. On‐line Quizzes are an opportunity to review lecture material. They are used to test recall of concepts, recognize drug mechanism of action and associated side‐effects and therapeutic use as well as distinguish particular features of specific drugs and/or drug classes (ie compare and contrast). Each quiz will be worth 10 pts each and you will be given 25 minutes to complete each quiz. Each of your top 8 quizzes will be worth 1% towards your final grade. They MAY be open book and MUST be completed individually. Midterms & Final will be MC questions, matching and short answer. Midterms will test recall of various mechanisms of action, associated side effects, adverse reactions, pharmacokinetics and therapeutic use. Key concepts of various classes and mechanisms will also be tested. A focus on integration of information and application of knowledge gained during course work will also be examined. All midterms will happen during lecture hours‐ locations TBD. Missed midterm exam make‐up will be at the discretion of the coordinator and may include: re‐calculation of points, sitting a separate make‐up exam, or an oral make‐up exam. The final exam will be cumulative and will involve longer answer written questions that integrate material discussed throughout the year; the date and place will be set by A&S. Drug Review written assignment will be posted on Blackboard and discussed during the first small group session. Your paper must be initially screened through “TURNITIN” prior to handing it in. Please see drug review assignment for information regarding assignment outcomes. http://www.utoronto.ca/ota/turnitin/index.html “Students agree that by taking this course all required papers may be subject to submission for textual similarity review to Turnitin.com for the detection of plagiarism. All submitted papers will be included as source documents in the Turnitin.com reference database solely for the purpose of detecting plagiarism of such papers. The terms that apply to the University’s use of the Turnitin.com service are described on the Turnitin.com web site.” Accessibility Needs: The University of Toronto is committed to accessibility. If you require accommodations or have any accessibility concerns, please visit http://studentlife.utoronto.ca/accessibility as soon as possible. ...
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