Lecture 2a - Lecture 2 overview degradation/damage of DNA...

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Lecture 2 overview degradation/damage of DNA bases s po nta ne o us  de purina tio n s po nta ne o us  de a m ina tio n o xida tio n thro ug h ‘na tura l’ pro c e s s e s o xida tio n b y drug s  a nd c he m ic a ls a lkyla tio n thro ug h ‘na tura l’ pro c e s s e s a lkyla tio n b y drug s  a nd c he m ic a ls Direct repair of base damage Base excision repair
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Spontaneous decomposition: DNA vs. RNA a ll b io lo g ic a l m a c ro m o le c ule s  s po nta ne o us ly de c o m po s e nuc le ic  a c ids  s po nta ne o us ly de c o m po s e  in s o lutio n RNA is more vulnerable than DNA to decomposition   b e c a us e  o f the  pre s e nc e  o f 2’-hydro xyl g ro up  o f rib o s e :  m a ke s  the  pho s pho die s te r b o nds  o f RNA m o le c ule s  ve ry  s us c e ptib le  to  hydro lys is , e s pe c ia lly in the  pre s e nc e  o f  diva le nt c a tio ns  (C a 2+ , Mg 2+ ) hence, RNA is adequate typically for ‘short-term storage’ of genetic  information e.g. viruses that use RNA as a ‘genome’, this carrier is  short-lived and mutation-prone 
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Spontaneous decomposition of DNA vs. RNA loss of 2’-OH group presence of 2’OH group phosphodiester bond more stable phosphodiester bond less stable
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Spontaneous decomposition of DNA DNA: rib o s e  s ug a r m o ie ty is  re duc e d to  
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This note was uploaded on 12/03/2010 for the course PHAMACOLOG pcl470 taught by Professor Arnot during the Fall '10 term at University of Toronto- Toronto.

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Lecture 2a - Lecture 2 overview degradation/damage of DNA...

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