Lecture 7 to post - Lecture 7 overview T h e c e llc y c le...

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Lecture 7 overview The  c e ll c yc le c yc lins  a nd c yc lin de pe nde nt kina s e s  (c dks ) c yc lin de pe nde nt kina s e  inhib ito rs The  c o nc e pt o f c he c kpo ints c e ll c yc le  c he c kpo ints drug s  a nd a g e nts  tha t im pa c t c e ll c yc le Ho w do  we  s tudy c he c kpo ints  in the  c e ll c yc le
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What is the cell cycle pro c e s s  o f c e ll re pro duc tio n tha t e nta ils  the re plic a tio n o f DNA fo llo we d b y  divis io n o f the  nuc le us  a nd  pa rtitio ning  o f the  c yto pla s m  to  yie ld two  da ug hte r c e lls   s e q ue ntia l a nd c yc lic a l ro utine   s ta g e s  a re  we ll-de fine d o ve ra ll c o ns e rva tio n in e uka ryo te s m a s te r re g ula to rs  a re  c o ns e rve d fro m  ye a s t to  hum a n
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The Essential Cell cycle two  e s s e ntia l c o m po ne nts :  S  a nd M pha s e s   (S ynthe s is  a nd Mito s is ) C e lls  in e a rly e m b ryo s :  pro c e e d thro ug h c o ntinuo us  c yc le s  o f DNA re plic a tio n  a nd nuc le a r divis io n (m ito s is ) a t g re a t s pe e d  – DNA re plic a tio n s ta rts  a s  s o o n a s  m ito s is  e nds   (ta ke s  ½  ho ur fo r c o m ple tio n o f o ne  ro und o f c e ll divis io n)
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Control of cell cycle La te r o n in e m b ryo g e ne s is  –  de c is io ns  b y a  c e ll to  unde rg o  divis io n a re  influe nc e d b y  dive rs e  m e ta b o lic , s tre s s   a nd e nviro nm e nta l c ue s   influe nc e  whe n a  c e ll s ho uld  unde rg o  DNA re plic a tio n a nd m ito s is An a dditio na l pha s e  (g a p pha s e ) c a lle d G 1 pha s e  o c c urs   b e twe e n m ito s is  a nd DNA s ynthe s is Ano the r g a p c a lle d G 2 pha s e  o c c urs  b e twe e n S  a nd M G 1 is  pe rio d whe n s ig na ls  inte rve ne  to  influe nc e  the  c e ll’s   de c is io n a s  to  whe the r o r no t to  e nte r S  pha s e G 2 is  pe rio d whe n s ig na ls  inte rve ne  to  influe nc e  de c is io n to   e nte r M pha s e O ne  pha s e  o uts ide  o f the  c e ll c yc le  : G 0 G1 G2
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Control of cell cycle progression: Cyclin-dependent kinases To  e nte r S  pha s e  o r M pha s e , c e ll m us t a c tiva te   cyclin- dependent kinases  (C DKs )  C DKs  a re  pro te in kina s e s  tha t re q uire  b inding  to  a no the r  pro te in kno wn a s  a   cyclin  to  b e c o m e  c a ta lytic a lly a c tive O nly a  s ing le  C DK c a ta lytic  s ub unit (C DK1 o r c dc 2) in  lo we r e uka ryo te s  e .g . S . c e re vis ia e  o r b udding  ye a s t Multiple  C dk kina s e s  with s ta g e  tra ns itio n-s pe c ific  ro le s   in m ultic e llula r e uka ryo te s Ac tivity a nd s ub s tra te  s pe c ific ity a re  re g ula te d b y the ir 
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Lecture 7 to post - Lecture 7 overview T h e c e llc y c le...

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