{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Lecture 7 to post - Lecture 7 overview T h e c e llc y c le...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 7 overview The  c e ll c yc le c yc lins  and c yc lin de pe nde nt kinas e s  (c dks ) c yc lin de pe nde nt kinas e  inhibito rs The  c o nc e pt o f c he c kpo ints c e ll c yc le  c he c kpo ints drug s  and ag e nts  that im pac t c e ll c yc le Ho w do  we  s tudy c he c kpo ints  in the  c e ll c yc le
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
What is the cell cycle pro c e s s  o f c e ll re pro duc tio n that e ntails  the re plic atio n o f DNA fo llo we d by  divis io n o f the  nuc le us  and  partitio ning  o f the  c yto plas m  to  yie ld two  daug hte r c e lls   s e q ue ntial and c yc lic al ro utine   s tag e s  are  we ll-de fine d o ve rall c o ns e rvatio n in e ukaryo te s m as te r re g ulato rs  are  c o ns e rve d fro m  ye as t to  hum an
Background image of page 2
The Essential Cell cycle two  e s s e ntial c o m po ne nts :  S  and M phas e s   (S ynthe s is  and Mito s is ) C e lls  in e arly e m bryo s :  pro c e e d thro ug h c o ntinuo us  c yc le s  o f DNA re plic atio n  and nuc le ar divis io n (m ito s is ) at g re at s pe e d  – DNA re plic atio n s tarts  as  s o o n as  m ito s is  e nds   (take s   ½  ho ur fo r c o m ple tio n o f o ne  ro und o f c e ll divis io n)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Control of cell cycle Late r o n in e m bryo g e ne s is  –  de c is io ns  by a c e ll to  unde rg o  divis io n are  influe nc e d by  dive rs e  m e tabo lic , s tre s s   and e nviro nm e ntal c ue s   influe nc e  whe n a c e ll s ho uld  unde rg o  DNA re plic atio n and m ito s is An additio nal phas e  (g ap phas e ) c alle d G 1 phas e  o c c urs   be twe e n m ito s is  and DNA s ynthe s is Ano the r g ap c alle d G 2 phas e  o c c urs  be twe e n S  and M G 1 is  pe rio d whe n s ig nals  inte rve ne  to  influe nc e  the  c e ll’s   de c is io n as  to  whe the r o r no t to  e nte r S  phas e G 2 is  pe rio d whe n s ig nals  inte rve ne  to  influe nc e  de c is io n to   e nte r M phas e O ne  phas e  o uts ide  o f the  c e ll c yc le  : G 0 G1 G2
Background image of page 4
Control of cell cycle progression: Cyclin-dependent kinases To  e nte r S  phas e  o r M phas e , c e ll m us t ac tivate   cyclin- dependent kinases  (C DKs )  C DKs  are  pro te in kinas e s  that re q uire  binding  to  ano the r  pro te in kno wn as  a  cyclin  to  be c o m e  c atalytic ally ac tive O nly a s ing le  C DK c atalytic  s ubunit (C DK1 o r c dc 2) in  lo we r e ukaryo te s  e .g . S . c e re vis iae  o r budding  ye as t Multiple  C dk kinas e s  with s tag e  trans itio n-s pe c ific  ro le s   in m ultic e llular e ukaryo te s
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}